Peripheral administration of interleukin-13 reverses inflammatory macrophage and tactile allodynia in mice with partial sciatic nerve ligation.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of pharmacological sciences"
DOI: 10.1016/j.jphs.2016.11.005
Abstract: Inflammatory macrophages play a fundamental role in neuropathic pain. In this study, we demonstrate the effects of peripheral interleukin-13 (IL-13) on neuropathic pain after partial sciatic nerve (SCN) ligation (PSL) in mice. IL-13 receptor α1… read more here.
Keywords: reverses inflammatory; inflammatory macrophage; tactile allodynia; partial sciatic ... See more keywords
Alternations in inflammatory macrophage niche drive phenotypic and functional plasticity of Kupffer cells
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DOI: 10.1038/s41467-024-53659-7
Abstract: Inflammatory signals lead to recruitment of circulating monocytes and induce their differentiation into pro-inflammatory macrophages. Therefore, whether blocking inflammatory monocytes can mitigate disease progression is being actively evaluated. Here, we employ multiple lineage-tracing models and… read more here.
Keywords: kupffer cells; macrophage niche; macrophage; niche ... See more keywords
Serine Promotes Inflammatory Macrophage Polarisation in Periodontitis via NAD+ Signalling.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of clinical periodontology"
DOI: 10.1111/jcpe.70058
Abstract: AIM To investigate the role of serine in modulating macrophage polarisation and periodontal inflammation. MATERIALS AND METHODS Saliva samples were obtained from periodontitis patients, healthy individuals and periodontitis remission patients for salivary metabolomics analysis. C57BL/6J… read more here.
Keywords: inflammatory macrophage; macrophage polarisation; periodontitis; serine ... See more keywords
Inflammatory macrophage to hepatocyte signals can be prevented by extracellular vesicle reprogramming
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cell Science"
DOI: 10.1242/jcs.260691
Abstract: ABSTRACT Macrophage-derived extracellular vesicles (EVs) play key roles in intercellular communication. Within the liver, they have been linked to several inflammatory diseases including nonalcoholic fatty liver disease (NAFLD). In this study, we found that inflammatory… read more here.
Keywords: signals prevented; hepatocyte signals; inflammatory; macrophage hepatocyte ... See more keywords
Regulation of Pro-Inflammatory Macrophage Polarization via Lipid Nanoparticles Mediated Delivery of Anti-Prostaglandin-E2 siRNA
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DOI: 10.3390/cimb45010001
Abstract: Pro-inflammatory macrophage polarization is crucial in acute inflammatory diseases like Acute lung injury (ALI), and acute respiratory distress syndrome (ARDS). Prostaglandin E2 (PGE2) is believed to promote inflammation in such cases. Therefore, our study aimed… read more here.
Keywords: macrophage polarization; sirna; pro inflammatory; macrophage ... See more keywords
Macrophage-Driven Inflammation in Metabolic Osteoarthritis: Implications for Biomarker and Therapy Development
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24076112
Abstract: Osteoarthritis (OA) is a common and debilitating joint disorder that leads to progressive joint breakdown and loss of articular cartilage. Accompanied by a state of low-grade inflammation, its etiology extends beyond that of a wear-and-tear… read more here.
Keywords: macrophage driven; driven inflammation; osteoarthritis; macrophage ... See more keywords