Peripheral administration of interleukin-13 reverses inflammatory macrophage and tactile allodynia in mice with partial sciatic nerve ligation.
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DOI: 10.1016/j.jphs.2016.11.005
Abstract: Inflammatory macrophages play a fundamental role in neuropathic pain. In this study, we demonstrate the effects of peripheral interleukin-13 (IL-13) on neuropathic pain after partial sciatic nerve (SCN) ligation (PSL) in mice. IL-13 receptor α1… read more here.
Keywords: reverses inflammatory; inflammatory macrophage; tactile allodynia; partial sciatic ... See more keywords
Inflammatory macrophage to hepatocyte signals can be prevented by extracellular vesicle reprogramming
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DOI: 10.1242/jcs.260691
Abstract: ABSTRACT Macrophage-derived extracellular vesicles (EVs) play key roles in intercellular communication. Within the liver, they have been linked to several inflammatory diseases including nonalcoholic fatty liver disease (NAFLD). In this study, we found that inflammatory… read more here.
Keywords: signals prevented; hepatocyte signals; inflammatory; macrophage hepatocyte ... See more keywords
Regulation of Pro-Inflammatory Macrophage Polarization via Lipid Nanoparticles Mediated Delivery of Anti-Prostaglandin-E2 siRNA
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DOI: 10.3390/cimb45010001
Abstract: Pro-inflammatory macrophage polarization is crucial in acute inflammatory diseases like Acute lung injury (ALI), and acute respiratory distress syndrome (ARDS). Prostaglandin E2 (PGE2) is believed to promote inflammation in such cases. Therefore, our study aimed… read more here.
Keywords: macrophage polarization; sirna; pro inflammatory; macrophage ... See more keywords
Macrophage-Driven Inflammation in Metabolic Osteoarthritis: Implications for Biomarker and Therapy Development
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DOI: 10.3390/ijms24076112
Abstract: Osteoarthritis (OA) is a common and debilitating joint disorder that leads to progressive joint breakdown and loss of articular cartilage. Accompanied by a state of low-grade inflammation, its etiology extends beyond that of a wear-and-tear… read more here.
Keywords: macrophage driven; driven inflammation; osteoarthritis; macrophage ... See more keywords