Toll-Like Receptor 2 Antagonist Ameliorates Type 2 Diabetes Mellitus Associated Neuropathic Pain by Repolarizing Pro-inflammatory Macrophages.
Sign Up to like & getrecommendations! Published in 2021 at "Neurochemical research"
DOI: 10.1007/s11064-021-03365-3
Abstract: Diabetic neuropathy is one of the common complications of type 2 diabetes mellitus (T2DM) with severe outcomes. The mechanisms of physiopathology of diabetic neuropathy are not well elucidated. Inflammation and inflammatory macrophages are recognized to… read more here.
Keywords: inflammatory macrophages; t2dm mice; pro inflammatory; diabetic neuropathy ... See more keywords
Thioredoxin as a marker for inflammatory macrophages
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.10.252
Abstract: Monocyte-derived macrophages are immune cells derived from hematopoietic progenitors. They interact with a variety of environmental stimuli and carry out highly variable functions, from pathogen phagocytosis to wound healing. Macrophages have traditionally been classified as… read more here.
Keywords: inflammatory macrophages; differentiated macrophages; thioredoxin marker; inflammatory ... See more keywords
One-Carbon Metabolism Supports S-Adenosylmethionine and Histone Methylation to Drive Inflammatory Macrophages.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular cell"
DOI: 10.1016/j.molcel.2019.06.039
Abstract: Activated macrophages adapt their metabolic pathways to drive the pro-inflammatory phenotype, but little is known about the biochemical underpinnings of this process. Here, we find that lipopolysaccharide (LPS) activates the pentose phosphate pathway, the serine… read more here.
Keywords: metabolism; one carbon; inflammatory macrophages; carbon metabolism ... See more keywords
Mitochondrial arginase-2 is essential for IL-10 metabolic reprogramming of inflammatory macrophages
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-21617-2
Abstract: Mitochondria are important regulators of macrophage polarisation. Here, we show that arginase-2 (Arg2) is a microRNA-155 (miR-155) and interleukin-10 (IL-10) regulated protein localized at the mitochondria in inflammatory macrophages, and is critical for IL-10-induced modulation… read more here.
Keywords: inflammatory macrophages; reprogramming inflammatory; essential metabolic; metabolic reprogramming ... See more keywords
Influx of podoplanin‐expressing inflammatory macrophages into the genital tract following Chlamydia infection
Sign Up to like & getrecommendations! Published in 2023 at "Immunology and Cell Biology"
DOI: 10.1111/imcb.12621
Abstract: Genital Chlamydia trachomatis infection remains a major health issue as it causes severe complications including pelvic inflammatory disease, ectopic pregnancy and infertility in females as a result of infection‐associated chronic inflammation. Podoplanin, a transmembrane receptor,… read more here.
Keywords: genital tract; infection; trachomatis; podoplanin expressing ... See more keywords
AB0057 THE ROLE OF NON-INFLAMMATORY MACROPHAGES INITIATING AND RESOLVING THE INFLAMMATORY RESPONSE OF MONOSODIUM URATE IN MICE
Sign Up to like & getrecommendations! Published in 2020 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2020-eular.335
Abstract: Gout is the most common chronic inflammatory arthritis around the world which is associated with many conditions that affect longevity and well-being, such as metabolic syndrome, cardiovascular diseases, and renal diseases. [1]Gout is the most… read more here.
Keywords: inflammatory response; production; arthritis; inflammatory macrophages ... See more keywords
Modulation of Inflamed Synovium Improves Migration of Mesenchymal Stromal Cells in Vitro Through Anti-Inflammatory Macrophages.
Sign Up to like & getrecommendations! Published in 2022 at "Cartilage"
DOI: 10.1177/19476035221085136
Abstract: OBJECTIVE Inflammation is known to negatively affect cartilage repair. However, it is unclear how inflammation influences the migration of mesenchymal stromal cells (MSCs) from the underlying bone marrow into the defect. We therefore aimed to… read more here.
Keywords: modulation; migration; inflammation; inflammatory macrophages ... See more keywords
Infiltration of inflammatory macrophages and neutrophils and widespread pyroptosis in lung drive influenza lethality in nonhuman primates
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1010395
Abstract: Severe influenza kills tens of thousands of individuals each year, yet the mechanisms driving lethality in humans are poorly understood. Here we used a unique translational model of lethal H5N1 influenza in cynomolgus macaques that… read more here.
Keywords: infiltration; pyroptosis; influenza; lung ... See more keywords
The generation, activation, and polarization of monocyte-derived macrophages in human malignancies
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1178337
Abstract: Macrophages are immune cells that originate from embryogenesis or from the differentiation of monocytes. They can adopt numerous phenotypes depending on their origin, tissue distribution and in response to different stimuli and tissue environment. Thus,… read more here.
Keywords: activation polarization; anti inflammatory; generation activation; polarization ... See more keywords
Natural Diterpenoid Oridonin Ameliorates Experimental Autoimmune Neuritis by Promoting Anti-inflammatory Macrophages Through Blocking Notch Pathway
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2019.00272
Abstract: The diterpenoid compound, Oridonin, extracted from the Chinese herb, Rabdosia rubescens, possesses multiple biological activities and properties. Oridonin exhibited efficient anti-inflammatory activity by inducing a switch in macrophage polarization to the anti-inflammatory phenotype through inhibition… read more here.
Keywords: anti inflammatory; inflammatory macrophages; autoimmune neuritis; notch pathway ... See more keywords
Gentiana scabra Restrains Hepatic Pro-Inflammatory Macrophages to Ameliorate Non-Alcoholic Fatty Liver Disease
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.816032
Abstract: Non-alcoholic fatty liver disease (NAFLD) has become a progressive metabolic disease that is emerging as a global epidemic. Considering that the complex pathogenesis has not been fully elucidated, barely specific pharmacological therapy is recommended in… read more here.
Keywords: inflammatory; non alcoholic; pro inflammatory; alcoholic fatty ... See more keywords