Toll-Like Receptor 2 Antagonist Ameliorates Type 2 Diabetes Mellitus Associated Neuropathic Pain by Repolarizing Pro-inflammatory Macrophages.
Sign Up to like & getrecommendations! Published in 2021 at "Neurochemical research"
DOI: 10.1007/s11064-021-03365-3
Abstract: Diabetic neuropathy is one of the common complications of type 2 diabetes mellitus (T2DM) with severe outcomes. The mechanisms of physiopathology of diabetic neuropathy are not well elucidated. Inflammation and inflammatory macrophages are recognized to… read more here.
Keywords: inflammatory macrophages; t2dm mice; pro inflammatory; diabetic neuropathy ... See more keywords
Thioredoxin as a marker for inflammatory macrophages
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.10.252
Abstract: Monocyte-derived macrophages are immune cells derived from hematopoietic progenitors. They interact with a variety of environmental stimuli and carry out highly variable functions, from pathogen phagocytosis to wound healing. Macrophages have traditionally been classified as… read more here.
Keywords: inflammatory macrophages; differentiated macrophages; thioredoxin marker; inflammatory ... See more keywords
One-Carbon Metabolism Supports S-Adenosylmethionine and Histone Methylation to Drive Inflammatory Macrophages.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular cell"
DOI: 10.1016/j.molcel.2019.06.039
Abstract: Activated macrophages adapt their metabolic pathways to drive the pro-inflammatory phenotype, but little is known about the biochemical underpinnings of this process. Here, we find that lipopolysaccharide (LPS) activates the pentose phosphate pathway, the serine… read more here.
Keywords: metabolism; one carbon; inflammatory macrophages; carbon metabolism ... See more keywords
Mitochondrial arginase-2 is essential for IL-10 metabolic reprogramming of inflammatory macrophages
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-21617-2
Abstract: Mitochondria are important regulators of macrophage polarisation. Here, we show that arginase-2 (Arg2) is a microRNA-155 (miR-155) and interleukin-10 (IL-10) regulated protein localized at the mitochondria in inflammatory macrophages, and is critical for IL-10-induced modulation… read more here.
Keywords: inflammatory macrophages; reprogramming inflammatory; essential metabolic; metabolic reprogramming ... See more keywords
Fever-range temperature alters continual efferocytosis mediated by mouse pro-inflammatory macrophages.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of leukocyte biology"
DOI: 10.1093/jleuko/qiaf061
Abstract: Fever, a cardinal sign of inflammation, has been shown to modulate macrophage functions. Here, we investigate whether fever affects macrophage efferocytosis. This process is essential for the resolution of inflammation and the return to homeostasis… read more here.
Keywords: temperature; febrile temperature; efferocytosis; pro inflammatory ... See more keywords
Influx of podoplanin‐expressing inflammatory macrophages into the genital tract following Chlamydia infection
Sign Up to like & getrecommendations! Published in 2023 at "Immunology and Cell Biology"
DOI: 10.1111/imcb.12621
Abstract: Genital Chlamydia trachomatis infection remains a major health issue as it causes severe complications including pelvic inflammatory disease, ectopic pregnancy and infertility in females as a result of infection‐associated chronic inflammation. Podoplanin, a transmembrane receptor,… read more here.
Keywords: genital tract; infection; trachomatis; podoplanin expressing ... See more keywords
NF-κB and TET2 promote macrophage reprogramming in hypoxia that overrides the immunosuppressive effects of the tumor microenvironment
Sign Up to like & getrecommendations! Published in 2024 at "Science Advances"
DOI: 10.1126/sciadv.adq5226
Abstract: Macrophages orchestrate tissue homeostasis and immunity. In the tumor microenvironment (TME), macrophage presence is largely associated with poor prognosis because of their reprogramming into immunosuppressive cells. We investigated the effects of hypoxia, a TME-associated feature,… read more here.
Keywords: promote macrophage; hypoxic inflammatory; tumor microenvironment; macrophage ... See more keywords
AB0057 THE ROLE OF NON-INFLAMMATORY MACROPHAGES INITIATING AND RESOLVING THE INFLAMMATORY RESPONSE OF MONOSODIUM URATE IN MICE
Sign Up to like & getrecommendations! Published in 2020 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2020-eular.335
Abstract: Gout is the most common chronic inflammatory arthritis around the world which is associated with many conditions that affect longevity and well-being, such as metabolic syndrome, cardiovascular diseases, and renal diseases. [1]Gout is the most… read more here.
Keywords: inflammatory response; production; arthritis; inflammatory macrophages ... See more keywords
Modulation of Inflamed Synovium Improves Migration of Mesenchymal Stromal Cells in Vitro Through Anti-Inflammatory Macrophages.
Sign Up to like & getrecommendations! Published in 2022 at "Cartilage"
DOI: 10.1177/19476035221085136
Abstract: OBJECTIVE Inflammation is known to negatively affect cartilage repair. However, it is unclear how inflammation influences the migration of mesenchymal stromal cells (MSCs) from the underlying bone marrow into the defect. We therefore aimed to… read more here.
Keywords: modulation; migration; inflammation; inflammatory macrophages ... See more keywords
Clonorchis sinensis extracellular vesicles associated with Csi-let-7a-5p activate pro-inflammatory macrophages to induce biliary injury
Sign Up to like & getrecommendations! Published in 2025 at "PLOS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0013080
Abstract: During Clonorchis sinensis (C. sinensis) infection, pro-inflammatory macrophages (M1 macrophages) are highly activated, yet their role in the disease remains poorly understood. Previous studies have demonstrated that extracellular vesicles from C. sinensis (CsEVs) can activate… read more here.
Keywords: csi let; sinensis; pro inflammatory; inflammatory macrophages ... See more keywords
Infiltration of inflammatory macrophages and neutrophils and widespread pyroptosis in lung drive influenza lethality in nonhuman primates
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1010395
Abstract: Severe influenza kills tens of thousands of individuals each year, yet the mechanisms driving lethality in humans are poorly understood. Here we used a unique translational model of lethal H5N1 influenza in cynomolgus macaques that… read more here.
Keywords: infiltration; pyroptosis; influenza; lung ... See more keywords