Bothrops lanceolatus snake (Fer-de-lance) venom triggers inflammatory mediators’ storm in human blood
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DOI: 10.1007/s00204-020-02959-0
Abstract: Systemic increased inflammatory mediators’ levels are a hallmark in a plethora of pathological conditions, including thrombotic diseases as the envenomation by Bothrops lanceolatus snake. Multiple organ infarctions, which are not prevented by anticoagulant therapy, are… read more here.
Keywords: venom; inflammatory mediators; blood; lanceolatus venom ... See more keywords
Gene expression profiles of pro-inflammatory mediators in the conjunctiva of patients with epiblepharon
Sign Up to like & getrecommendations! Published in 2021 at "Graefe's Archive for Clinical and Experimental Ophthalmology"
DOI: 10.1007/s00417-021-05089-0
Abstract: To investigate the gene expression of pro-inflammatory mediators in the conjunctiva of pediatric patients with epiblepharon in a case-control study. Twenty healthy controls and 15 pediatric patients with epiblepharon were enrolled from April 23, 2020… read more here.
Keywords: patients epiblepharon; inflammatory mediators; gene expression; expression ... See more keywords
Soluble inflammatory mediators of synoviocytes stimulated by monosodium urate crystals induce the production of oxidative stress, pain, and inflammation mediators in chondrocytes
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DOI: 10.1007/s10067-021-05676-w
Abstract: We hypothesized that the secretion of inflammatory mediators from synoviocytes affects the chondrocyte homeostasis of articular cartilage. This study was a preliminary attempt to elucidate the molecular mechanisms by which soluble mediators obtained from activated… read more here.
Keywords: urate crystals; monosodium urate; inflammatory mediators; oxidative stress ... See more keywords
Cross-Talk between Glia, Neurons and Mast Cells in Neuroinflammation Associated with Parkinson’s Disease
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DOI: 10.1007/s11481-017-9766-1
Abstract: Parkinson’s disease (PD) is a progressive movement disorder characterized by neuroinflammation and dopaminergic neurodegeneration in the brain. 1-methyl-4-phenylpyridinium (MPP+), a metabolite of the parkinsonian neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induces the release of inflammatory mediators from glial… read more here.
Keywords: mast cells; inflammatory mediators; glia neurons; mast cell ... See more keywords
Effect of probiotic Lactobacillus rhamnosus by-products on gingival epithelial cells challenged with Porphyromonas gingivalis.
Sign Up to like & getrecommendations! Published in 2021 at "Archives of oral biology"
DOI: 10.1016/j.archoralbio.2021.105174
Abstract: OBJECTIVE Probiotics are usually given as living cells, but their effects may be also achieved by postbiotics. We hypothesized that probiotics products (spent media and lysate) altered the response induced by P. gingivalis in gingival… read more here.
Keywords: epithelial cells; gingival epithelial; inflammatory mediators; gingivalis ... See more keywords
Caffeoyloxy-5,6-dihydro-4-methyl-(2H)-pyran-2-one isolated from the leaves of Olinia usambarensis attenuates LPS-induced inflammatory mediators by inactivating AP-1 and NF-κB.
Sign Up to like & getrecommendations! Published in 2019 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2019.06.031
Abstract: We have previously reported the isolation of four compounds, caffeoyloxy-5,6-dihydro-4-methyl-(2H)-pyran-2-one (CDMP), olinioside, caffeic acid and 3-hydroxylup-12-en-28-oic acid, from the leaves of Olinia usambarensis. Here, we evaluated the inhibitory effects of these compounds on lipopolysaccharide (LPS)-induced… read more here.
Keywords: caffeoyloxy dihydro; lps induced; dihydro methyl; inflammatory mediators ... See more keywords
Hyperglycemia induces inflammatory mediators in the human chorionic villous
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DOI: 10.1016/j.cyto.2018.07.020
Abstract: HighlightsHyperglycemic activate caspase‐1 and downstream inflammatory cytokine production.Inflammatory mediators contribute insulin‐resistance during diabetic condition.In mild gestational hyperglycemia the activation of inflammasomes may be associated with complications. Abstract This study was based on the hypothesis that… read more here.
Keywords: gestational hyperglycemia; chorionic villous; inflammatory mediators; inflammatory cytokine ... See more keywords
Crosstalk between inflammatory mediators and endoplasmic reticulum stress in liver diseases.
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DOI: 10.1016/j.cyto.2018.10.018
Abstract: An excessive inflammatory response is frequently associated with cellular dysfunction and cell death. The latter may cause single and multiple organ failure. The most susceptible organs are liver, lung, kidney, heart and intestine. This review… read more here.
Keywords: endoplasmic reticulum; inflammatory mediators; inflammatory response; response ... See more keywords
Distinct inflammatory mediator patterns in young black and white adults: The African-predict study.
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DOI: 10.1016/j.cyto.2019.154894
Abstract: OBJECTIVE Inflammatory mediators have been implicated in the early stages of cardiovascular disease development, including hypertension. Since global reports reflect a higher hypertension prevalence in black than white populations, we hypothesise the involvement of specific… read more here.
Keywords: black white; inflammatory mediators; blood pressure; inflammatory mediator ... See more keywords
l-Arginine and allopurinol supplementation attenuates inflammatory mediators in human osteoblasts-osteoarthritis cells.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2018.06.047
Abstract: This study investigated the synergistic effects of l-arginine and allopurinol on antioxidant and inflammatory mediators in human osteoblasts-osteoarthritis (HOb-OA) cells. The cells were treated with allopurinol (50-150 mg/kg bwt) and l-arginine (50-150 mg/kg bwt) for 72 h. Cell… read more here.
Keywords: supplementation; osteoblasts osteoarthritis; inflammatory mediators; arginine allopurinol ... See more keywords
GTS-21, an α7nAChR agonist, suppressed the production of key inflammatory mediators by PBMCs that are elevated in COPD patients and associated with impaired lung function
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DOI: 10.1016/j.imbio.2020.151950
Abstract: Abstract Chronic obstructive pulmonary disease (COPD) is a lung inflammatory disease characterized by progressive airflow limitation, chronic respiratory symptoms and frequent exacerbations. There is an unmet need to identify novel therapeutic alternatives beside bronchodilators that… read more here.
Keywords: impaired lung; production; inflammatory mediators; key inflammatory ... See more keywords