Integrated Cascade Nanozyme Remodels Chondrocyte Inflammatory Microenvironment in Temporomandibular Joint Osteoarthritis via Inhibiting ROS‐NF‐κB and MAPK Pathways
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202203195
Abstract: Temporomandibular joint osteoarthritis (TMJ OA) is a degenerative joint disease with no complete cure at present. Notably, the inflammatory microenvironment in TMJ OA is modulated by oxidative stress, which impacts cartilage metabolism, chondrocyte apoptosis, inflammatory… read more here.
Keywords: inhibiting ros; microenvironment; inflammatory microenvironment; temporomandibular joint ... See more keywords
Loss of BMI‐1 dampens migration and EMT of colorectal cancer in inflammatory microenvironment through TLR4/MD‐2/MyD88‐mediated NF‐κB signaling
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26353
Abstract: Increasing evidence from various clinical and experimental studies has demonstrated that the inflammatory microenvironment created by immune cells facilitates tumor migration. Epithelial‐mesenchymal transition (EMT) is involved in the progression of cancer invasion and metastasis in… read more here.
Keywords: bmi; inflammatory microenvironment; migration; cancer ... See more keywords
ROS/Electro Dual-Reactive Nanogel for Targeting Epileptic Foci to Remodel Aberrant Circuits and Inflammatory Microenvironment.
Sign Up to like & getrecommendations! Published in 2023 at "ACS nano"
DOI: 10.1021/acsnano.3c01140
Abstract: Medicinal treatment against epilepsy is faced with intractable problems, especially epileptogenesis that cannot be blocked by clinical antiepileptic drugs (AEDs) during the latency of epilepsy. Abnormal circuits of neurons interact with the inflammatory microenvironment of… read more here.
Keywords: electro dual; epileptic foci; ros electro; nanogel ... See more keywords
Visualization of epithelial-mesenchymal transition in an inflammatory microenvironment–colorectal cancer network
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-52816-z
Abstract: Epithelial-mesenchymal transition (EMT) is a biological process by which epithelial cells acquire mesenchymal characteristics. In malignant tumors, EMT is crucial for acquisition of a mesenchymal phenotype with invasive and metastatic properties, leading to tumor progression.… read more here.
Keywords: mesenchymal transition; colorectal cancer; inflammatory microenvironment; epithelial mesenchymal ... See more keywords
Key biomarkers within the colorectal cancer related inflammatory microenvironment
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-86941-5
Abstract: Therapeutic approaches focused on the inflammatory microenvironment are currently gaining more support, as biomolecules involved in the inflammatory colorectal cancer (CRC) tumor microenvironment are being explored. We analyzed tumor and paired normal tissue samples from… read more here.
Keywords: microenvironment; colorectal cancer; inflammatory microenvironment; tissue ... See more keywords
Palovarotene Can Attenuate Heterotopic Ossification Induced by Tendon Stem Cells by Downregulating the Synergistic Effects of Smad and NF-κB Signaling Pathway following Stimulation of the Inflammatory Microenvironment
Sign Up to like & getrecommendations! Published in 2022 at "Stem Cells International"
DOI: 10.1155/2022/1560943
Abstract: Heterotopic ossification (HO) is defined as the formation of bone tissues outside the bones, such as in the muscles. Currently, the mechanism of HO is still unclear. Tendon stem cells (TSCs) play important roles in… read more here.
Keywords: stem cells; inflammatory microenvironment; palovarotene; smad signaling ... See more keywords
Endothelial Cells Promote Migration of Mesenchymal Stem Cells via PDGF-BB/PDGFRβ-Src-Akt in the Context of Inflammatory Microenvironment upon Bone Defect
Sign Up to like & getrecommendations! Published in 2022 at "Stem Cells International"
DOI: 10.1155/2022/2401693
Abstract: Homing of mesenchymal stem cells (MSCs) to the defect site is indispensable for bone repair. Local endothelial cells (ECs) can recruit MSCs; however, the mechanism remains unclear, especially in the context of the inflammatory microenvironment.… read more here.
Keywords: pdgf; inflammatory microenvironment; pdgf pdgfr; src akt ... See more keywords
Cannabidiol Promotes Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells in the Inflammatory Microenvironment via the CB2-dependent p38 MAPK Signaling Pathway
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Stem Cells"
DOI: 10.15283/ijsc21152
Abstract: Background and Objectives Chronic inflammation of bone tissue often results in bone defects and hazards to tissue repair and regeneration. Cannabidiol (CBD) is a natural cannabinoid with multiple biological activities, including anti-inflammatory and osteogenic potential.… read more here.
Keywords: inflammatory microenvironment; stem cells; differentiation; mapk ... See more keywords
Both the Infection Status and Inflammatory Microenvironment Induce Transcriptional Remodeling in Macrophages in Murine Leishmanial Lesions
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Parasitology"
DOI: 10.1645/22-94
Abstract: Cutaneous leishmaniasis is caused by infection with the protozoan parasite Leishmania, which resides intracellularly in dermal macrophages (Mø), producing lesions. The skin lesions are characterized by proinflammatory cytokines and growth factors as well as inflammatory… read more here.
Keywords: microenvironment; infection; inflammatory microenvironment; transcriptional remodeling ... See more keywords
Inflammatory Microenvironment Accelerates Bone Marrow Mesenchymal Stem Cell Aging
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.870324
Abstract: MSC senescence is considered a contributing factor in aging-related diseases. We investigated the influence of the inflammatory microenvironment on bone marrow mesenchymal stem cells (BMSCs) under aging conditions and the underlying mechanism to provide new… read more here.
Keywords: bone marrow; inflammatory microenvironment; stem cell;
Exploration of the Immune-Related Long Noncoding RNA Prognostic Signature and Inflammatory Microenvironment for Cervical Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.870221
Abstract: Purpose: Our research developed immune-related long noncoding RNAs (lncRNAs) for risk stratification in cervical cancer (CC) and explored factors of prognosis, inflammatory microenvironment infiltrates, and chemotherapeutic therapies. Methods: The RNA-seq data and clinical information of… read more here.
Keywords: cervical cancer; related long; inflammatory microenvironment; long noncoding ... See more keywords