Ly-6Chigh inflammatory-monocyte recruitment is regulated by p38 MAPK/MCP-1 activation and promotes ventilator-induced lung injury.
Sign Up to like & getrecommendations! Published in 2019 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2019.106015
Abstract: Lymphocyte antigen 6Chigh (Ly-6Chigh) inflammatory monocytes, as novel mononuclear cells in the innate immune system, participate in infectious diseases. In this study, we investigated the potential role of these monocytes in ventilator-induced lung injury (VILI)… read more here.
Keywords: ventilator induced; inflammatory; 6chigh inflammatory; inflammatory monocytes ... See more keywords
LncRNA lncLy6C induced by microbiota metabolite butyrate promotes differentiation of Ly6Chigh to Ly6Cint/neg macrophages through lncLy6C/C/EBPβ/Nr4A1 axis
Sign Up to like & getrecommendations! Published in 2020 at "Cell Discovery"
DOI: 10.1038/s41421-020-00211-8
Abstract: Macrophages are mainly divided into two populations, which play a different role in physiological and pathological conditions. The differentiation of these cells may be regulated by transcription factors. However, it is unclear how to modulate… read more here.
Keywords: ly6c high; promotes differentiation; neg macrophages; inflammatory monocytes ... See more keywords
Inflammatory monocytes promote pre-engraftment syndrome and tocilizumab can therapeutically limit pathology in patients
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-24412-1
Abstract: Unrelated cord blood transplantation (UCBT) is an effective treatment for hematopoietic disorders. However, this attractive approach is frequently accompanied by pre-engraftment syndrome (PES), severe cases of PES are associated with enhanced mortality and morbidity, but… read more here.
Keywords: engraftment syndrome; pathology; pre engraftment; monocytes promote ... See more keywords
Ly6Chi inflammatory monocytes promote susceptibility to Leishmania donovani infection
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-14935-3
Abstract: Ly6Chi inflammatory monocytes (iMO) are critical for host defense against toxoplasmosis and malaria but their role in leishmaniasis is unclear. In this study, we report a detrimental role of Ly6Chi iMOs in visceral leishmaniasis (VL)… read more here.
Keywords: ly6chi imos; inflammatory monocytes; donovani infection; ly6chi inflammatory ... See more keywords
Calming egress of inflammatory monocytes and related septic shock by therapeutic CCR2 silencing using macrophage-derived extracellular vesicles.
Sign Up to like & getrecommendations! Published in 2022 at "Nanoscale"
DOI: 10.1039/d1nr06922e
Abstract: Uncontrolled inflammation, featuring the aggravated mobilization of Ly6Chigh inflammatory monocytes (Mos), may cause high morbidity and mortality in the pathogenesis of sepsis-associated immune disorders. Inspired by the similar membrane protein profile of extracellular vehicles (EVs)… read more here.
Keywords: inflammatory monocytes; ccr2; inflammatory; egress inflammatory ... See more keywords
Pathogenic T-cells and inflammatory monocytes incite inflammatory storms in severe COVID-19 patients
Sign Up to like & getrecommendations! Published in 2020 at "National Science Review"
DOI: 10.1093/nsr/nwaa041
Abstract: Pathogenic human coronavirus infections, such as severe acute respiratory syndrome CoV (SARS-CoV) and Middle East respiratory syndrome CoV (MERS-CoV), cause high morbidity and mortality1, 2 Recently, a severe pneumonia-associated respiratory syndrome caused by a new… read more here.
Keywords: respiratory syndrome; covid patients; cells inflammatory; inflammatory monocytes ... See more keywords
Leishmania donovani Metacyclic Promastigotes Impair Phagosome Properties in Inflammatory Monocytes
Sign Up to like & getrecommendations! Published in 2021 at "Infection and Immunity"
DOI: 10.1128/iai.00009-21
Abstract: Leishmaniasis, a debilitating disease with clinical manifestations ranging from self-healing ulcers to life-threatening visceral pathologies, is caused by protozoan parasites of the Leishmania genus. These professional vacuolar pathogens are transmitted by infected sand flies to… read more here.
Keywords: promastigotes impair; impair phagosome; leishmania donovani; donovani metacyclic ... See more keywords
Inflammatory Monocytes Promote Granuloma-Mediated Control of Persistent Salmonella Infection
Sign Up to like & getrecommendations! Published in 2022 at "Infection and Immunity"
DOI: 10.1128/iai.00070-22
Abstract: Persistent infections generally involve a complex balance between protective immunity and immunopathology. We used a murine model to investigate the role of inflammatory monocytes in immunity and host defense against persistent salmonellosis. ABSTRACT Persistent infections… read more here.
Keywords: inflammatory monocytes; persistent salmonellosis; inflammatory; immunity ... See more keywords
Dangerous Liaisons between Tet2 Mutation, Inflammatory Monocytes, and Leukemogenesis.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-22-0846
Abstract: Transgenic knockin mice expressing a common loss-of-function mutation in human TET2 exhibit aging-related accelerated myeloid leukemia development and skewing of myelopoiesis toward the production of proinflammatory MHC-IIhi monocytes that may contribute to disease. See related… read more here.
Keywords: dangerous liaisons; inflammatory monocytes; liaisons tet2; tet2 mutation ... See more keywords
Inflammatory and non-inflammatory monocytes as novel prognostic biomarkers of survival in SOD1G93A mouse model of Amyotrophic Lateral Sclerosis
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DOI: 10.1371/journal.pone.0184626
Abstract: Amyotrophic Lateral Sclerosis (ALS) has lately become a suitable scenario to study the interplay between the hematopoietic system and disease progression. Recent studies in C9orf72 null mice have demonstrated that C9orf72 is necessary for the… read more here.
Keywords: inflammatory; non inflammatory; amyotrophic lateral; model ... See more keywords
Control of Listeria monocytogenes infection requires classical IL-6 signaling in myeloid cells
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0203395
Abstract: IL-6 is required for the response of mice against Listeria monocytogenes. Control of infection depends on classical IL-6 signaling via membrane IL-6Rα, but IL-6 target cells and protective mechanisms remain unclear. We used mice with… read more here.
Keywords: myeloid cells; control; classical signaling; control listeria ... See more keywords