Translation-dependent unwinding of stem–loops by UPF1 licenses Regnase-1 to degrade inflammatory mRNAs
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DOI: 10.1093/nar/gkz628
Abstract: Abstract Regnase-1-mediated mRNA decay (RMD), in which inflammatory mRNAs harboring specific stem–loop structures are degraded, is a critical part of proper immune homeostasis. Prior to initial translation, Regnase-1 associates with target stem–loops but does not… read more here.
Keywords: stem loops; translation; inflammatory mrnas; regnase ... See more keywords