Conditional expression of HIV-1 Tat in the mouse alters the onset and progression of tonic, inflammatory, and neuropathic hypersensitivity in a sex-dependent manner.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pain"
DOI: 10.1002/ejp.1618
Abstract: At least one third of HIV-1-afflicted individuals experience peripheral neuropathy. Although the underlying mechanisms are not known, they may involve neurotoxic HIV-1 proteins. We assessed the influence of the neurotoxic HIV-1 regulatory protein, Tat, on… read more here.
Keywords: hiv; sex; hiv tat; hypersensitivity ... See more keywords
HNTX-III Alleviates Inflammatory and Neuropathic Pain in Animal Models
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Peptide Research and Therapeutics"
DOI: 10.1007/s10989-018-9729-2
Abstract: Voltage-gated sodium channel plays a critical role in pain sensation and has been considered as a potential target for the development of analgesic drug. Hainantoxin-III(HNTX-III) is a selective inhibitor of neuronal tetrodotoxin-sensitive voltage-gated sodium channels… read more here.
Keywords: inflammatory neuropathic; neuropathic pain; hntx iii; pain ... See more keywords
BK Potassium Channels Suppress Cavα2δ Subunit Function to Reduce Inflammatory and Neuropathic Pain.
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.01.073
Abstract: Cavα2δ subunits contribute to the cell-surface expression of Cav2 calcium channels. Upregulation of Cavα2δ-1 in dorsal root ganglion neurons occurs after nerve injury and results in an increased synaptic abundance of Cav2.2 channels in the… read more here.
Keywords: potassium channels; neuropathic pain; subunit; cav subunit ... See more keywords
The synergistic effects of Opioid and neuropeptide B/W in rat acute inflammatory and neuropathic pain models.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2021.173979
Abstract: The use of morphine is controversial due to the incidence of rewarding behavior, respiratory depression, and tolerance, leading to increased drug dose requirements, advancing to morphine addiction. To overcome these barriers, strategies have been taken… read more here.
Keywords: synergistic effects; morphine; neuropathic pain; inflammatory neuropathic ... See more keywords
Icariside II, a Prenyl-Flavonol, Alleviates Inflammatory and Neuropathic Pain by Inhibiting T-Type Calcium Channels and USP5-Cav3.2 Interactions.
Sign Up to like & getrecommendations! Published in 2023 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.3c00083
Abstract: Cav3.2 channels play an important role in the afferent nociceptive pathway, which is responsible for both physiological and pathological pain transmission. Cav3.2 channels are upregulated during neuropathic pain or peripheral inflammation in part due to… read more here.
Keywords: cav3 channels; cav3; neuropathic pain; pain ... See more keywords
The Endogenous Cannabinoid System: A Budding Source of Targets for Treating Inflammatory and Neuropathic Pain
Sign Up to like & getrecommendations! Published in 2018 at "Neuropsychopharmacology"
DOI: 10.1038/npp.2017.204
Abstract: A great need exists for the development of new medications to treat pain resulting from various disease states and types of injury. Given that the endogenous cannabinoid (that is, endocannabinoid) system modulates neuronal and immune… read more here.
Keywords: system; endogenous cannabinoid; pain; neuropathic pain ... See more keywords
Treatment With the Delta Opioid Agonist UFP-512 Alleviates Chronic Inflammatory and Neuropathic Pain: Mechanisms Implicated
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2019.00283
Abstract: We investigated whether administration of the δ-opioid receptor (DOR) agonist H-Dmt-Tic-NH-CH(CH2-COOH)-Bid (UFP-512), which also activates nuclear factor erythroid 2-related factor 2 (Nrf2), alleviated chronic inflammatory and/or neuropathic pain and inhibited the depressive-like behaviors associated with… read more here.
Keywords: ufp 512; agonist; pain; chronic inflammatory ... See more keywords
Effect of palmitoylethanolamide on inflammatory and neuropathic pain in rats
Sign Up to like & getrecommendations! Published in 2017 at "Korean Journal of Anesthesiology"
DOI: 10.4097/kjae.2017.70.5.561
Abstract: Background A growing body of evidence suggests that neuroinflammation, which is characterized by infiltration of immune cells, activation of mast cells and glial cells, and production of inflammatory mediators in the peripheral and central nervous… read more here.
Keywords: palmitoylethanolamide inflammatory; pain; neuropathic pain; effect palmitoylethanolamide ... See more keywords