Antioxidant Cascade Nanoenzyme Antagonize Inflammatory Pain by Modulating MAPK/p‐65 Signaling Pathway
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202206934
Abstract: Chronic pain has attracted wide interest because it is a major obstacle affecting the quality of life. Consequently, safe, efficient, and low‐addictive drugs are highly desirable. Nanoparticles (NPs) with robust anti‐oxidative stress and anti‐inflammatory properties… read more here.
Keywords: signaling pathway; mapk signaling; sfz nps; cascade nanoenzyme ... See more keywords
Focal mu-opioid receptor activation promotes neuroinflammation and microglial activation in the mesocorticolimbic system: Alterations induced by inflammatory pain.
Sign Up to like & getrecommendations! Published in 2023 at "Glia"
DOI: 10.1002/glia.24374
Abstract: Microglia participates in the modulation of pain signaling. The activation of microglia is suggested to play an important role in affective disorders that are related to a dysfunction of the mesocorticolimbic system (MCLS) and are… read more here.
Keywords: mesocorticolimbic system; pain; inflammatory pain; activation ... See more keywords
Prostaglandin E2 Upregulated Trigeminal Ganglionic Sodium Channel 1.7 Involving Temporomandibular Joint Inflammatory Pain in Rats
Sign Up to like & getrecommendations! Published in 2017 at "Inflammation"
DOI: 10.1007/s10753-017-0552-2
Abstract: Prostaglandin E2 (PGE2) is a key proinflammatory mediator that contributes to inflammatory hyperalgesia. Voltage-gated sodium channel 1.7 (Nav1.7) plays an important role in inflammatory pain. However, the modulation of Nav1.7 in inflammatory pain remains poorly… read more here.
Keywords: inflammatory pain; temporomandibular joint; sodium channel; inflammatory ... See more keywords
BDNF Activates mTOR to Upregulate NR2B Expression in the Rostral Anterior Cingulate Cortex Required for Inflammatory Pain-Related Aversion in Rats
Sign Up to like & getrecommendations! Published in 2018 at "Neurochemical Research"
DOI: 10.1007/s11064-018-2470-6
Abstract: The mechanistic target of rapamycin (mTOR) has been demonstrated to mediate pain-related aversion induced by formalin in the rostral anterior cingulate cortex (rACC). However, it remains unclear the signaling pathways and regulatory proteins involved. In… read more here.
Keywords: related aversion; inflammatory pain; mtor; pain related ... See more keywords
Analgesic Effect of Methane Rich Saline in a Rat Model of Chronic Inflammatory Pain
Sign Up to like & getrecommendations! Published in 2018 at "Neurochemical Research"
DOI: 10.1007/s11064-018-2490-2
Abstract: How oxidative stress contributes to neuro-inflammation and chronic pain is documented, and methane is reported to protect against ischemia–reperfusion injury in the nervous system via anti-inflammatory and antioxidant properties. We studied whether methane in the… read more here.
Keywords: inflammatory pain; pain; methane; chronic inflammatory ... See more keywords
Formalin-induced inflammatory pain increases excitability in locus coeruleus neurons
Sign Up to like & getrecommendations! Published in 2021 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2021.04.002
Abstract: Chronic pain is recognized as an important problem in communities. The Locus coeruleus (LC) with extensive ascending and descending projections has a critical role in modulating pain. Some studies indicate how the locus coeruleus-noradrenaline system… read more here.
Keywords: neurons formalin; inflammatory pain; locus coeruleus; formalin induced ... See more keywords
Peripheral and central sites of action for anti‐allodynic activity induced by the bifunctional opioid/NPFF receptors agonist BN‐9 in inflammatory pain model
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2017.07.044
Abstract: ABSTRACT The activation of opioid and neuropeptide FF (NPFF) receptors plays important roles to modulate nociceptive signal in inflammatory pain states. Recently, BN‐9 (Tyr‐D. Ala‐Gly‐Phe‐Gln‐Pro‐Gln‐Arg‐Phe‐NH2) was pharmacologically characterized as a novel bifunctional agonist at both… read more here.
Keywords: anti allodynic; inflammatory pain; model; npff receptors ... See more keywords
Intrathecally administered perampanel alleviates neuropathic and inflammatory pain in rats.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.172949
Abstract: Chronic pain conditions such as neuropathic pain and persistent inflammatory pain are difficult to manage. Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors modulate nociceptive processing at the spinal dorsal horn. Previous studies have shown that intrathecal AMPA receptor… read more here.
Keywords: neuropathic inflammatory; inflammatory pain; pain; ampa receptor ... See more keywords
Thymulin treatment attenuates inflammatory pain by modulating spinal cellular and molecular signaling pathways
Sign Up to like & getrecommendations! Published in 2019 at "International Immunopharmacology"
DOI: 10.1016/j.intimp.2019.02.042
Abstract: Abstract Thymulin is a peptide hormone which is mainly produced by thymic epithelial cells and it has immune‐modulatory and anti‐inflammatory effects. In this study, we investigated the effects of different doses and various timings of… read more here.
Keywords: treatment; inflammatory pain; thymulin; treatment attenuates ... See more keywords
Involvement of glycine receptor α1 subunits in cannabinoid-induced analgesia
Sign Up to like & getrecommendations! Published in 2018 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2018.01.041
Abstract: ABSTRACT Some cannabinoids have been shown to suppress chronic pain by targeting glycine receptors (GlyRs). Although cannabinoid potentiation of &agr;3 GlyRs is thought to contribute to cannabinoid‐induced analgesia, the role of cannabinoid potentiation of &agr;1… read more here.
Keywords: agr; inflammatory pain; pain; cannabinoid ... See more keywords
Up-regulating TIPE2 alleviates inflammatory pain by suppressing microglial activation-mediated inflammatory response via inhibiting Rac1/NF-κB pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2021.112631
Abstract: TNF-α-inducible protein 8-like 2 (TIPE2) is a recently discovered regulator of inflammation that can maintain immune homeostasis, exerting a significant role in the development of inflammation-related diseases. Here, we aimed to explore the role and… read more here.
Keywords: inflammatory pain; tipe2; expression; pain ... See more keywords