Cholinergic anti‐inflammatory pathway confers airway protection against oxidative damage and attenuates inflammation in an allergic asthma model
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29101
Abstract: Asthma is characterized by the influx of inflammatory cells, especially of eosinophils as well as reactive oxygen species (ROS) production, driven by the release of the T helper 2 (Th2)‐cell‐associated cytokines. The cholinergic anti‐inflammatory pathway… read more here.
Keywords: anti inflammatory; inflammation; inflammation allergic; inflammatory pathway ... See more keywords
Donepezil Prevents Inhibition of Cerebral Energetic Metabolism Without Altering Behavioral Parameters in Animal Model of Obesity
Sign Up to like & getrecommendations! Published in 2020 at "Neurochemical Research"
DOI: 10.1007/s11064-020-03107-x
Abstract: Obesity is characterized by chronic inflammation of low grade. The cholinergic anti-inflammatory pathway favors the reduction of the inflammatory response. In this work the effect of stimulation of the cholinergic anti-inflammatory pathway on SHIRPA behavioral… read more here.
Keywords: anti inflammatory; donepezil; donepezil prevents; inflammatory pathway ... See more keywords
The cholinergic anti‐inflammatory pathway: an innovative treatment strategy for respiratory diseases and their comorbidities
Sign Up to like & getrecommendations! Published in 2018 at "Current Opinion in Pharmacology"
DOI: 10.1016/j.coph.2017.12.003
Abstract: HighlightsThe cholinergic anti‐inflammatory pathway modulates inflammatory responses.The &agr;7nAChR is the critical target on inflammatory cells in this pathway.Recent studies newly revealed neuron‐ILC2s interactions in allergic inflammation.Neuroimmune interactions are potential therapeutic targets for lung diseases. &NA;… read more here.
Keywords: anti inflammatory; cholinergic anti; inflammatory responses; inflammatory pathway ... See more keywords
Sevoflurane-induced inflammation development: involvement of cholinergic anti-inflammatory pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Behavioural Pharmacology"
DOI: 10.1097/fbp.0000000000000507
Abstract: Chronic inflammation plays an important role in the mechanisms underpinning the development of anesthesia-induced cognitive dysfunction. However, less is known about how anesthesia causes inflammation. One possibility is that the inflammation is related to alteration… read more here.
Keywords: anti inflammatory; cholinergic anti; sevoflurane induced; inflammatory pathway ... See more keywords
Role of Cholinergic Anti-Inflammatory Pathway in Protecting Sepsis-Induced Acute Lung Injury through Regulation of the Conventional Dendritic Cells
Sign Up to like & getrecommendations! Published in 2022 at "Mediators of Inflammation"
DOI: 10.1155/2022/1474891
Abstract: Background The cholinergic anti-inflammatory pathway connects the immune response system and the nervous system via the vagus nerve. The key regulatory receptor is the α7-subtype of the nicotinic acetylcholine receptor (α7nAChR). Cholinergic anti-inflammatory pathway has… read more here.
Keywords: anti inflammatory; inflammatory pathway; conventional dcs; cholinergic anti ... See more keywords
Niloticin binds to MD-2 to promote anti-inflammatory pathway activation in macrophage cells
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Immunopathology and Pharmacology"
DOI: 10.1177/03946320221133017
Abstract: Objectives Niloticin is an active compound isolated from Cortex phellodendri with uncharacterized anti-inflammatory activity. We assessed the drug potential of niloticin and examined its ability to target myeloid differentiation protein 2 (MD-2) to ascertain the… read more here.
Keywords: inflammatory pathway; pharmacology; anti inflammatory; niloticin binds ... See more keywords
Homocysteine mediates transcriptional changes of the inflammatory pathway signature genes in human retinal pigment epithelial cells.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of ophthalmology"
DOI: 10.18240/ijo.2017.05.06
Abstract: AIM To test whether homocysteine (Hcy) can influence the transcriptional profile, we hypothesized that Hcy can lead to the induction of proinflammatory molecules in the retinal cells of aging people. METHODS An unbiased in vitro… read more here.
Keywords: hcy; pigment epithelial; retinal cells; inflammatory pathway ... See more keywords
Alpha-ketoglutarate suppresses the NF-κB-mediated inflammatory pathway and enhances the PXR-regulated detoxification pathway.
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.16875
Abstract: Alpha-ketoglutarate (AKG) is a critical nutritional factor in the maintenance of intestinal homeostasis. However, the relative mechanism of AKG has not been well understood. It was recently shown that the interaction between nuclear factor kappa… read more here.
Keywords: alpha ketoglutarate; regulated detoxification; pxr regulated; pathway ... See more keywords
Cholinergic Anti-inflammatory Pathway and Stroke.
Sign Up to like & getrecommendations! Published in 2017 at "Current drug delivery"
DOI: 10.2174/1567201814666170201150015
Abstract: BACKGROUND Stroke is devastating cerebrovascular event which is responsible for 6.7 million deaths each year worldwide. Inflammation plays an important role in the pathophysiology of stroke. Targeting inflammation after stroke is highly actual topic for… read more here.
Keywords: anti inflammatory; cholinergic anti; inflammation; inflammatory pathway ... See more keywords
Activation of the Cholinergic Anti-Inflammatory Pathway as a Novel Therapeutic Strategy for COVID-19
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.595342
Abstract: The outbreak of coronavirus disease 2019 (COVID-19) underlined the urgent need for alleviating cytokine storm. We propose here that activating the cholinergic anti-inflammatory pathway (CAP) is a potential therapeutic strategy. However, there is currently no… read more here.
Keywords: anti inflammatory; therapeutic strategy; pathway; inflammatory pathway ... See more keywords
Electroacupuncture Ameliorates Acute Pancreatitis: A Role for the Vagus Nerve–Mediated Cholinergic Anti-Inflammatory Pathway
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2021.647647
Abstract: Organ failure resulting from excessive inflammation is the leading cause of death in the early phase of acute pancreatitis (AP). The autonomic nervous system was reported to be involved in AP, and the vagus nerve… read more here.
Keywords: anti inflammatory; acute pancreatitis; vagus nerve; inflammatory pathway ... See more keywords