Accumulation of Damaging Lipids in the Arf1‐Ablated Neurons Promotes Neurodegeneration through Releasing mtDNA and Activating Inflammatory Pathways in Microglia
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202414260
Abstract: Lipid metabolism disorders in both neurons and glial cells have been found in neurodegenerative (ND) patients and animal models. However, the pathological connection between lipid droplets and NDs remains poorly understood. The recent work has… read more here.
Keywords: mtdna; inflammatory pathways; activating inflammatory; accumulation damaging ... See more keywords
Perturbations in common and distinct inflammatory pathways associated with morning and evening fatigue in outpatients receiving chemotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.5435
Abstract: Moderate to severe fatigue occurs in up to 94% of patients with cancer. Recent evidence suggests that morning and evening fatigue are distinct dimensions of physical fatigue. The purposes of this study were to evaluate… read more here.
Keywords: common distinct; evening fatigue; inflammatory pathways; fatigue ... See more keywords
Effects of tart cherry and its metabolites on aging and inflammatory conditions: Efficacy and possible mechanisms
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DOI: 10.1016/j.arr.2021.101254
Abstract: Inflammation is an underlying cause of or a contributing factor to a number of chronic conditions, including hypertension, insulin resistance, arthritis, and cognitive disorders. A chronic inflammatory state is also associated with aging. Tart cherry… read more here.
Keywords: tart cherry; active compounds; inflammatory; cherry metabolites ... See more keywords
Inflammatory Pathways in CVD and Diabetes: Broad-Spectrum Versus Selective Targeting.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American College of Cardiology"
DOI: 10.1016/j.jacc.2018.04.093
Abstract: Targeting inflammation is increasingly recognized as a novel therapeutic option in the management of type 2 diabetes and prevention of recurrent cardiovascular disease (CVD). In CANTOS (Canakinumab Anti-inflammatory Thrombosis Outcomes Study), canakinumab had similar magnitude… read more here.
Keywords: pathways cvd; inflammatory pathways; broad spectrum; cvd diabetes ... See more keywords
Short-term ozone exposure and metabolic status in metabolically healthy obese and normal-weight young adults: A viewpoint of inflammatory pathways.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of hazardous materials"
DOI: 10.1016/j.jhazmat.2021.127462
Abstract: Unhealthy metabolic status increases risks of cardiovascular and other diseases. This study aims to explore whether there is a link between O3 and metabolic health indicators through a viewpoint of inflammatory pathways. 49 metabolically healthy… read more here.
Keywords: status; viewpoint inflammatory; normal weight; metabolic status ... See more keywords
Contribution of inflammatory pathways to Fabry disease pathogenesis.
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DOI: 10.1016/j.ymgme.2017.09.004
Abstract: Lysosomal storage diseases are usually considered to be pathologies in which the passive deposition of unwanted materials leads to functional changes in lysosomes. Lysosomal deposition of unmetabolized glycolipid substrates stimulates the activation of pathogenic cascades,… read more here.
Keywords: contribution inflammatory; fabry disease; inflammation; disease ... See more keywords
Novel Sigma-1 receptor agonist alleviates renal ischemic injury by targeting apoptotic and inflammatory pathways
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DOI: 10.1038/s41598-025-23459-0
Abstract: Renal ischemia-reperfusion injury (IRI) is a major cause of acute kidney injury, yet its mechanisms remain unclear, and effective treatments are lacking. We previously showed that the Sigma-1 receptor (S1R) agonist fluvoxamine protects against IRI… read more here.
Keywords: sigma receptor; iri; inflammatory pathways; injury ... See more keywords
Hepatic protective effects of sulforaphane through the modulation of inflammatory pathways
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Asian Natural Products Research"
DOI: 10.1080/10286020.2019.1581174
Abstract: Abstract The aim of this study was to investigate the effects of sulforaphane (SFN) on lipopolysaccharide (LPS)-induced liver failure, and to elucidate underlying mechanisms. SFN, a natural isothiocyanate present in cruciferous vegetables such as broccoli… read more here.
Keywords: modulation inflammatory; sulforaphane modulation; effects sulforaphane; inflammatory pathways ... See more keywords
Icosabutate: targeting metabolic and inflammatory pathways for the treatment of NASH
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Investigational Drugs"
DOI: 10.1080/13543784.2022.2159804
Abstract: ABSTRACT Introduction Via pleiotropic targeting of membrane and nuclear fatty acid receptors regulating key metabolic and inflammatory pathways in the liver, long-chain omega-3 fatty acids could offer a unique therapeutic approach for the treatment of… read more here.
Keywords: treatment nash; metabolic inflammatory; inflammatory pathways; inflammatory ... See more keywords
Mouse models of COVID-19 recapitulate inflammatory pathways rather than gene expression
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DOI: 10.1101/2022.02.24.481866
Abstract: BACKGROUND How well mouse models recapitulate the transcriptional profiles seen in humans remains debatable, with both conservation and diversity identified in various settings. The K18-hACE2 mouse model has been widely used for evaluation of new… read more here.
Keywords: inflammatory pathways; mouse; recapitulate inflammatory; covid recapitulate ... See more keywords
Dysfunctional regulation of pivotal and key inflammatory pathways in infertile Indian women with genital tuberculosis
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Reproductive Immunology"
DOI: 10.1111/aji.13624
Abstract: Diagnosis of female genital tuberculosis (FGTB) remains elusive due to the paucibacillary nature of the disease. We evaluated if analysis of inflammatory pathways of endometrial tissue could establish a better diagnosis of FGTB. read more here.
Keywords: genital tuberculosis; regulation pivotal; inflammatory pathways; dysfunctional regulation ... See more keywords