Inhibition of SIK2 and SIK3 during differentiation enhances the anti-inflammatory phenotype of macrophages
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DOI: 10.1042/bcj20160646
Abstract: The salt-inducible kinases (SIKs) control a novel molecular switch regulating macrophage polarization. Pharmacological inhibition of the SIKs induces a macrophage phenotype characterized by the secretion of high levels of anti-inflammatory cytokines, including interleukin (IL)-10, and… read more here.
Keywords: anti inflammatory; inhibition sik2; differentiation; macrophage ... See more keywords
Comment on: Transcriptomic analysis of CFTR-impaired endothelial cells reveals a pro-inflammatory phenotype
Sign Up to like & getrecommendations! Published in 2021 at "European Respiratory Journal"
DOI: 10.1183/13993003.01365-2021
Abstract: We read with interest the article “Transcriptomic analysis of CFTR-impaired endothelial cells reveals a pro-inflammatory phenotype” by Declercq et al. [1]. Cystic fibrosis transmembrane conductance regulator (CFTR) is a cyclic adenosine monophosphate (cAMP)-dependent and ATP-gated… read more here.
Keywords: cftr; transcriptomic analysis; endothelial cells; inflammatory phenotype ... See more keywords
Mycobacterium tuberculosis Virulent Factor ESAT-6 Drives Macrophage Differentiation Toward the Pro-inflammatory M1 Phenotype and Subsequently Switches It to the Anti-inflammatory M2 Phenotype
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2018.00327
Abstract: Tuberculosis, a human infectious disease caused by Mycobacterium tuberculosis (M.tb), is still a major cause of morbidity and mortality worldwide. The success of M.tb as a pathogen relies mainly on its ability to divert the… read more here.
Keywords: phenotype; tuberculosis; differentiation; inflammatory phenotype ... See more keywords
Dihydronicotinamide Riboside Is a Potent NAD+ Precursor Promoting a Pro-Inflammatory Phenotype in Macrophages
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.840246
Abstract: Nicotinamide adenine dinucleotide (NAD) metabolism plays an important role in the regulation of immune function. However, a complete picture of how NAD, its metabolites, precursors, and metabolizing enzymes work together in regulating immune function and… read more here.
Keywords: inflammatory phenotype; nad precursor; potent nad; pro inflammatory ... See more keywords
HAPLN1 Affects Cell Viability and Promotes the Pro-Inflammatory Phenotype of Fibroblast-Like Synoviocytes
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DOI: 10.3389/fimmu.2022.888612
Abstract: HAPLN1 maintains aggregation and the binding activity of extracellular matrix (ECM) molecules (such as hyaluronic acid and proteoglycan) to stabilize the macromolecular structure of the ECM. An increase in HAPLN1 expression is observed in a… read more here.
Keywords: phenotype fibroblast; hapln1; expression; pro inflammatory ... See more keywords
Insulin-Like Growth Factor 1 Attenuates the Pro-Inflammatory Phenotype of Neutrophils in Myocardial Infarction
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.908023
Abstract: Acute myocardial infarction (MI) induces an extensive sterile inflammation, which is dominated in the early phase by invading neutrophils and monocytes/macrophages. The inflammatory response after MI critically affects infarct healing and cardiac remodeling. Therefore, modulation… read more here.
Keywords: phenotype; myocardial infarction; inflammatory; pro inflammatory ... See more keywords