A Balance between Pro‐Inflammatory and Pro‐Reparative Macrophages is Observed in Regenerative D‐MAPS
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202204882
Abstract: Microporous annealed particle scaffolds (MAPS) are a new class of granular materials generated through the interlinking of tunable microgels, which produce an interconnected network of void space. These microgel building blocks can be designed with… read more here.
Keywords: inflammatory pro; pro reparative; reparative macrophages; pro inflammatory ... See more keywords
Acute and subacute oral administration of mycotoxin deoxynivalenol exacerbates the pro-inflammatory and pro-pruritic responses in a mouse model of allergic dermatitis
Sign Up to like & getrecommendations! Published in 2020 at "Archives of Toxicology"
DOI: 10.1007/s00204-020-02875-3
Abstract: Deoxynivalenol (DON) contamination in food is a public health concern; however, the effect of DON exposure on immune disorders including allergies remains unclear. The aim of this study is to elucidate the effect of oral… read more here.
Keywords: inflammatory pro; responses mouse; exposure; pruritic responses ... See more keywords
Inflammatory and Pro-resolving Mediators in Frontotemporal Dementia and Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2019 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2019.09.008
Abstract: Chronic inflammation contributes to neuronal death in Alzheimer's disease (AD) and frontotemporal dementia (FTD). Here we evaluated inflammatory and pro-resolving mediators in AD and behavioural variant of FTD (bvFTD) patients compared with controls, since neuroinflamamtion… read more here.
Keywords: frontotemporal dementia; resolving mediators; pro resolving; inflammatory pro ... See more keywords
Bioengineered NanoAid synergistically targets inflammatory pro-tumor processes to advance glioblastoma chemotherapy.
Sign Up to like & getrecommendations! Published in 2025 at "Nanoscale"
DOI: 10.1039/d4nr04557b
Abstract: Through transcriptomic analysis of patient-derived glioblastoma tissues, we identify an overactivation of inflammatory pathways that contribute to the development of a tumor-promoting microenvironment and therapeutic resistance. To address this critical mechanism, we present NanoAid, a… read more here.
Keywords: pro tumor; processes advance; inflammatory pro; advance glioblastoma ... See more keywords
SPMs exert anti-inflammatory and pro-resolving effects through positive allosteric modulation of the prostaglandin EP4 receptor
Sign Up to like & getrecommendations! Published in 2024 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2407130121
Abstract: Significance Specialized pro-resolving mediators (SPMs) are poly-unsaturated fatty acid derivatives, which have anti-inflammatory and pro-resolving properties. However, their mechanism of action is still unclear. Here, we report that major synthetic SPMs function as positive allosteric… read more here.
Keywords: receptor; inflammatory pro; pro resolving; positive allosteric ... See more keywords
Hepcidin attenuates amyloid beta‐induced inflammatory and pro‐oxidant responses in astrocytes and microglia
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.14005
Abstract: Alzheimer's disease (AD) is characterized by extracellular senile plaques, intracellular neurofibrillary tangles, and neuronal death. Aggregated amyloid‐β (Aβ) induces inflammation and oxidative stress, which have pivotal roles in the pathogenesis of AD. Hepcidin is a… read more here.
Keywords: anti inflammatory; pro oxidant; astrocytes microglia; inflammatory pro ... See more keywords
Long-term mitapivat treatment improves inflammatory pro-fibrotic cardiomyopathy in a murine model of β-thalassemia.
Sign Up to like & getrecommendations! Published in 2025 at "Blood"
DOI: 10.1182/blood-2025-727
Abstract: Hypertrophic cardiomyopathy (HC) is a severe invalidating complication of ß–thalassemia (ß–thal), contributing to reduced patients' life expectancy. Recently we showed that 12-months old male ß-thal mice develop HC independently from heart iron accumulation, and that… read more here.
Keywords: mice; mitapivat; pro fibrotic; heart ... See more keywords
Aspirin modulates production of pro-inflammatory and pro-resolving mediators in endothelial cells
Sign Up to like & getrecommendations! Published in 2023 at "PLOS ONE"
DOI: 10.1371/journal.pone.0283163
Abstract: Endothelial cells synthesize biochemical signals to coordinate a response to insults, resolve inflammation and restore barrier integrity. Vascular cells release a variety of vasoactive bioactive lipid metabolites during the inflammatory response and produce pro-resolving mediators… read more here.
Keywords: inflammatory pro; endothelial cells; pro resolving; production ... See more keywords