The Causal Relationship Between Circulating Inflammatory Proteins and Tinnitus: A Mendelian Randomization Study Mediated by Blood Metabolites
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DOI: 10.1002/brb3.70699
Abstract: Tinnitus is a complex disease whose pathophysiological mechanisms are still not fully elucidated. Dysregulation of circulating inflammatory proteins and metabolites is thought to play a crucial role in tinnitus pathophysiology, but the causal relationships and… read more here.
Keywords: inflammatory proteins; circulating inflammatory; proteins tinnitus; causal relationship ... See more keywords
Tau/α‐synuclein ratio and inflammatory proteins in Parkinson's disease: An exploratory study
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DOI: 10.1002/mds.27001
Abstract: Background: No CSF or plasma biomarker has been validated for diagnosis or progression of PD. read more here.
Keywords: proteins parkinson; ratio inflammatory; synuclein ratio; tau synuclein ... See more keywords
Peripheral viral challenge triggers hippocampal production of inflammatory proteins
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DOI: 10.1007/s11011-017-0030-4
Abstract: Peripheral viral infections increase seizure propensity and intensity in susceptible individuals. We have modeled this comorbidity by demonstrating that intraperitoneal (ip) injection of the conventional viral mimetic, polyinosinic-polycytidylic acid (PIC), renders the brain hypersusceptible to… read more here.
Keywords: challenge; pic challenge; increase; peripheral viral ... See more keywords
Association between circulating inflammatory proteins and benign prostatic disease: a Mendelian randomization study
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DOI: 10.1038/s41598-024-74737-2
Abstract: Previous research has suggested that circulating inflammatory proteins are associated with benign prostatic disease (BPD). This Mendelian randomization (MR) study was conducted to further investigate the causal relationship between 91 inflammatory proteins and BPD. Genome-wide… read more here.
Keywords: value; inflammatory proteins; circulating inflammatory; association ... See more keywords
Genetic prediction of immune cells, inflammatory proteins, and metabolite-mediated association between gut microbiota and COPD: a Mendelian randomization study
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DOI: 10.1038/s41598-025-05290-9
Abstract: Observational studies have suggested a potential association between the gut microbiota and chronic obstructive pulmonary disease (COPD); however, the causal relationship between them, as well as the mediating roles of metabolites, inflammatory proteins, and immune… read more here.
Keywords: copd; gut microbiota; inflammatory proteins; microbiota copd ... See more keywords
Mendelian randomization and genetic analyses reveal causal roles of immune cells and inflammatory proteins in keratoconus
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DOI: 10.1038/s41598-025-10759-8
Abstract: Immunity and inflammation are implicated in the progression of keratoconus (KC), but the causal relationships between inflammatory immune phenotypes and the disease remain unclear. We conducted a comprehensive Mendelian randomization (MR) analysis using GWAS data… read more here.
Keywords: genetic analyses; inflammatory proteins; immune cells; mendelian randomization ... See more keywords
Predicting the hub interactome of COVID-19 and oral squamous cell carcinoma: uncovering ALDH-mediated Wnt/β-catenin pathway activation via salivary inflammatory proteins
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DOI: 10.1038/s41598-025-88819-2
Abstract: Understanding shared pathways and mechanisms involved in the pathogenesis of diseases like oral squamous cell carcinoma (OSCC) and COVID-19 could lead to the development of novel therapeutic strategies and diagnostic biomarkers. This study aims to… read more here.
Keywords: inflammatory proteins; oral squamous; accuracy; squamous cell ... See more keywords
Genetic causality of circulating inflammatory proteins and plasma metabolites in coronary atherosclerosis.
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DOI: 10.1093/postmj/qgaf145
Abstract: BACKGROUND Coronary atherosclerosis is a leading cause of cardiovascular disease and death worldwide. Despite progress in understanding its pathogenesis, the roles of circulating inflammatory proteins and plasma metabolites are complex and not fully elucidated. Existing… read more here.
Keywords: coronary atherosclerosis; inflammatory proteins; circulating inflammatory; atherosclerosis ... See more keywords
The Causal Relationships Between Inflammatory Proteins, Brain Structure, and Psychiatric Disorders: A Two-Step Mendelian Randomization Analysis.
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DOI: 10.1093/schbul/sbae208
Abstract: BACKGROUND AND HYPOTHESIS Inflammatory proteins are implicated in psychiatric disorders, but the causality and underlying mechanisms remain unclear. STUDY DESIGN We conducted bidirectional Mendelian randomization (MR) using genetic variants from genome-wide association studies (GWAS) for… read more here.
Keywords: inflammatory proteins; psychiatric disorders; analysis; mendelian randomization ... See more keywords
The effect of inflammatory proteins on COVID-19 is mediated by blood metabolites: A Mendelian randomization study
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DOI: 10.1097/md.0000000000041852
Abstract: Several studies have suggested that inflammatory proteins may be associated with Coronavirus disease 2019 (COVID-19). However, the specific causal relationship between the 2 and whether blood metabolites act as mediators remains unclear. Therefore, the purpose… read more here.
Keywords: proteins covid; blood metabolites; inflammatory proteins; mendelian randomization ... See more keywords
Immune cells, inflammatory proteins, and sepsis: A mediation Mendelian randomization study
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DOI: 10.1097/md.0000000000043779
Abstract: Immune cells are known to be associated with sepsis. However, whether these associations represent a causal relationship and whether inflammatory proteins act as mediators remain unclear. A mediation Mendelian Randomization (MR) approach was employed to… read more here.
Keywords: inflammatory proteins; immune cells; mediation mendelian; mendelian randomization ... See more keywords