Vitamin D Inhibits Adipokine Production and Inflammatory Signaling Through the Vitamin D Receptor in Human Adipocytes
Sign Up to like & getrecommendations! Published in 2021 at "Obesity"
DOI: 10.1002/oby.23109
Abstract: The purpose of this study was to investigate the effects of vitamin D on adipokine expression and inflammation in human adipose tissues and adipocytes and evaluate the molecular mechanisms involved. read more here.
Keywords: inhibits adipokine; inflammatory signaling; vitamin inhibits; signaling vitamin ... See more keywords
Berberine as a natural modulator of inflammatory signaling pathways in the immune system: Focus on NF‐κB, JAK/STAT, and MAPK signaling pathways
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7407
Abstract: Three main inflammatory signaling pathways include nuclear factor‐κB (NF‐κB), Janus kinases/Signal transducer and activator of transcriptions (JAKs/STATs), and mitogen‐activated protein kinases (MAPKs) play crucial roles in inducing, promoting, and regulating inflammatory responses in the immune… read more here.
Keywords: inflammatory signaling; signaling pathways; inflammatory diseases; immune system ... See more keywords
GIGYF1/2-Driven Cooperation between ZNF598 and TTP in Posttranscriptional Regulation of Inflammatory Signaling.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.03.006
Abstract: Inflammatory signaling is restricted through degradation and the translational repression of cytokine mRNAs. A key factor in this regulation is tristetraprolin (TTP), an RNA-binding protein (RBP) that recruits RNA-destabilizing factors and the translation inhibitory complex… read more here.
Keywords: regulation inflammatory; znf598; inflammatory signaling; regulation ... See more keywords
Stress axis variability is associated with differential ozone‐induced lung inflammatory signaling and injury biomarker response
Sign Up to like & getrecommendations! Published in 2018 at "Environmental Research"
DOI: 10.1016/j.envres.2018.09.007
Abstract: ABSTRACT Ozone (O3), a ubiquitous urban air pollutant, causes adverse pulmonary and extrapulmonary effects. A large variability in acute O3‐induced effects has been observed; however, the basis for interindividual differences in susceptibility is unclear. We… read more here.
Keywords: response; stress axis; inflammatory signaling; stress ... See more keywords
The metabolic regulator Lamtor5 suppresses inflammatory signaling via regulating mTOR-mediated TLR4 degradation
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Immunology"
DOI: 10.1038/s41423-019-0281-6
Abstract: Comprehensive immune responses are essential for eliminating pathogens but must be tightly controlled to avoid sustained immune activation and potential tissue damage. The engagement of TLR4, a canonical pattern recognition receptor, has been proposed to… read more here.
Keywords: metabolic regulator; degradation; regulator lamtor5; inflammatory signaling ... See more keywords
Injury-induced inflammatory signaling and hematopoiesis in Drosophila
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2119109119
Abstract: Significance We explore mechanisms by which stress caused by acute injury affects blood cell development and inflammatory response in Drosophila. Similar to their mammalian myeloid counterparts, these cells are predisposed to sense and react to… read more here.
Keywords: injury induced; induced inflammatory; signaling hematopoiesis; injury ... See more keywords
PP4 inhibition sensitizes ovarian cancer to NK cell-mediated cytotoxicity via STAT1 activation and inflammatory signaling
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1101/2022.08.25.505192
Abstract: Background Increased infiltration of T cells into ovarian tumors has been repeatedly shown to be predictive of enhanced patient survival. However, despite the evidence of an active immune response in ovarian cancer (OC), the frequency… read more here.
Keywords: cell; inflammatory signaling; activation; pp4 inhibition ... See more keywords
Digital lamellar inflammatory signaling in an experimental model of equine preferential weight bearing
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Veterinary Internal Medicine"
DOI: 10.1111/jvim.16662
Abstract: Abstract Background Supporting limb laminitis (SLL) is a complication of severe orthopedic disease in horses and is often life‐limiting, yet the pathophysiology remains obscure. Hypothesis/Objectives To investigate the role of digital lamellar inflammatory signaling in… read more here.
Keywords: digital lamellar; inflammatory signaling; lamellar inflammatory; weight bearing ... See more keywords
Regulation of osteoclast differentiation and inflammatory signaling by TCF8 in periodontitis.
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DOI: 10.1111/odi.14623
Abstract: OBJECTIVES The aim of this study was to explore the potential role of zinc-finger homeodomain transcription factor (TCF8) in osteoclastogenesis and inflammation during periodontitis. MATERIALS AND METHODS Rats with periodontitis were induced via Porphyromonas gingivalis-lipopolysaccharide… read more here.
Keywords: osteoclast differentiation; tcf8; inflammatory signaling; differentiation inflammatory ... See more keywords
NPT1220-312, a TLR2/TLR9 Small Molecule Antagonist, Inhibits Pro-Inflammatory Signaling, Cytokine Release, and NLRP3 Inflammasome Activation
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Inflammation"
DOI: 10.1155/2022/2337363
Abstract: Toll-like receptors (TLRs) play a critical role in innate immune system responses to damage-associated molecular patterns (DAMPs) and pathogen-associated molecular patterns (PAMPs). A growing body of evidence suggests that excessive TLR-mediated innate immune system activation… read more here.
Keywords: inflammatory signaling; tlr2 tlr9; release; pro inflammatory ... See more keywords
Abstract 992: IL-6/STAT3-mediated inflammatory signaling results in dysregulated fibroblast growth factor receptor activation and tumor cell signaling in human pancreatic adenocarcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.am2020-992
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is a devastating malignancy characterized by delayed diagnosis and the lowest five-year survival amongst all cancer sites. PDAC development and progression are attributed to chronic inflammation and associated tissue repair mechanisms… read more here.
Keywords: growth factor; inflammatory signaling; fibroblast growth; cancer ... See more keywords