Indole-3-propionic acid mitigates chlorpyrifos-mediated neurotoxicity by modulating cholinergic and redox-regulatory systems, inflammatory stress, apoptotic responses and DNA damage in rats.
Sign Up to like & getrecommendations! Published in 2021 at "Environmental toxicology and pharmacology"
DOI: 10.1016/j.etap.2021.103786
Abstract: This study probed the neuroprotective influence of indole-3-propionic acid (IPA) in rats exposed to chlorpyrifos (CPF) alone at 5mg/kg body weight or co-administered with IPA at 12.5 and 25mg/kg for 14 days. Behavioral data indicated… read more here.
Keywords: damage; propionic acid; redox regulatory; inflammatory stress ... See more keywords
Phosphatidylcholine restores neuronal plasticity of neural stem cells under inflammatory stress
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-02361-5
Abstract: The balances between NSCs growth and differentiation, and between glial and neuronal differentiation play a key role in brain regeneration after any pathological conditions. It is well known that the nervous tissue shows a poor… read more here.
Keywords: phosphatidylcholine restores; neuronal plasticity; differentiation; neuronal differentiation ... See more keywords
Reduced secretion of LCN2 (lipocalin 2) from reactive astrocytes through autophagic and proteasomal regulation alleviates inflammatory stress and neuronal damage.
Sign Up to like & getrecommendations! Published in 2023 at "Autophagy"
DOI: 10.1080/15548627.2023.2180202
Abstract: LCN2/neutrophil gelatinase-associated lipocalin/24p3 (lipocalin 2) is a secretory protein that acts as a mammalian bacteriostatic molecule. Under neuroinflammatory stress conditions, LCN2 is produced and secreted by activated microglia and reactive astrocytes, resulting in neuronal apoptosis.… read more here.
Keywords: reactive astrocytes; reduced secretion; lcn2; stress neuronal ... See more keywords
Inflammatory stress signaling via NF-kB alters accessible cholesterol to upregulate SREBP2 transcriptional activity in endothelial cells
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.05.05.490737
Abstract: There is a growing appreciation that a tight relationship exists between cholesterol homeostasis and immunity in leukocytes, however, this relationship has not been deeply explored in the vascular endothelium. Endothelial cells (ECs) rapidly respond to… read more here.
Keywords: endothelial cells; accessible cholesterol; cholesterol homeostasis; cholesterol ... See more keywords
Chlorogenic Acid Alleviates the Inflammatory Stress of LPS-Induced BV2 Cell via Interacting with TLR4-Mediated Downstream Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Computational and Mathematical Methods in Medicine"
DOI: 10.1155/2022/6282167
Abstract: Background Neuroinflammation is related with the inflammatory stress of brain tissue induced by the activation of microglial in the central nervous system (CNS), which is still an intractable disease for modern clinical system. Chlorogenic acid… read more here.
Keywords: chlorogenic acid; acid; lps induced; inflammatory stress ... See more keywords
Oscillating Glucose Induces the Increase in Inflammatory Stress through Ninjurin-1 Up-Regulation and Stimulation of Transport Proteins in Human Endothelial Cells
Sign Up to like & getrecommendations! Published in 2023 at "Biomolecules"
DOI: 10.3390/biom13040626
Abstract: Clinical data implicate fluctuations of high levels of plasma glucose in cardiovascular diseases. Endothelial cells (EC) are the first cells of the vessel wall exposed to them. Our aim was to evaluate the effects of… read more here.
Keywords: transport proteins; endothelial cells; transport; regulation ... See more keywords
Lactobacillus paracasei KW3110 Prevents Inflammatory-Stress-Induced Mitochondrial Dysfunction in Mouse Macrophages
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23031443
Abstract: Lactobacillus paracasei KW3110 (KW3110) has anti-inflammatory effects, including the prevention of blue light exposure induced retinal inflammation and ageing-related chronic inflammation in mice. The mechanism involves the promotion of anti-inflammatory cytokine interleukin (IL)-10 production by… read more here.
Keywords: dysfunction; kw3110; induced mitochondrial; stress induced ... See more keywords
Effects of Allyl Isothiocyanate on Oxidative and Inflammatory Stress in Type 2 Diabetic Rats
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27175568
Abstract: Oxidative stress and inflammation play a crucial role in the pathogenesis and progression of diabetes. Currently, there is a growing need to exploit plant-derived bioactive compounds to support conventional therapies. The purpose of this study… read more here.
Keywords: stress; diabetic rats; inflammation; allyl isothiocyanate ... See more keywords