Infliximab Trough Levels Are Not Predictive of Relapse in Patients with IBD in Endoscopic Remission: A Multicenter Cohort Study
Sign Up to like & getrecommendations! Published in 2020 at "Digestive Diseases and Sciences"
DOI: 10.1007/s10620-020-06645-0
Abstract: Therapeutic drug monitoring (TDM) is important in optimizing use of biologics in inflammatory bowel diseases (IBD). However, the role of proactive TDM during remission remains uncertain. This retrospective study included patients receiving infliximab (IFX) therapy… read more here.
Keywords: trough levels; remission; study; relapse ... See more keywords
Success and safety of high infliximab trough levels in inflammatory bowel disease
Sign Up to like & getrecommendations! Published in 2018 at "Scandinavian Journal of Gastroenterology"
DOI: 10.1080/00365521.2018.1486882
Abstract: Abstract Objective: A prospective trial suggests target infliximab trough levels of 3–7 μg/mL, yet data on additional therapeutic benefits and safety of higher trough levels are scarce. Aim: To explore whether high infliximab trough levels (≥7 μg/mL)… read more here.
Keywords: trough levels; high trough; high infliximab; disease ... See more keywords
Infliximab Trough Levels Are Associated With Mucosal Healing During Maintenance Treatment With Infliximab in Paediatric Crohn’s Disease
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Crohn's and Colitis"
DOI: 10.1093/ecco-jcc/jjy155
Abstract: Background and Aims Mucosal healing is an important treatment goal in Crohn's disease. We investigated the association between serum infliximab trough levels and mucosal healing, and the infliximab cut-off levels required for mucosal healing in… read more here.
Keywords: infliximab trough; trough levels; mucosal healing; crohn disease ... See more keywords
Infliximab Trough Levels Are Associated With Transmural Sonographic Healing in Inflammatory Bowel Disease.
Sign Up to like & getrecommendations! Published in 2022 at "Inflammatory bowel diseases"
DOI: 10.1093/ibd/izac186
Abstract: BACKGROUND Mucosal healing improves clinical outcomes in patients with inflammatory bowel disease (IBD) and is associated with higher infliximab trough levels (ITLs). Transmural healing, assessed by intestinal ultrasound (IUS), is emerging as an objective target… read more here.
Keywords: trough levels; disease; itl; inflammatory bowel ... See more keywords
Early Infliximab Trough Levels Predict the Long-term Efficacy of Infliximab in a Randomized Controlled Trial in Patients with Active Crohn’s Disease Comparing, between CT-P13 and Originator Infliximab
Sign Up to like & getrecommendations! Published in 2022 at "Gut and Liver"
DOI: 10.5009/gnl220005
Abstract: Background/Aims The clinical efficacy and safety of CT-P13 are comparable to originator infliximab for Crohn’s disease in CT-P13 3.4 study (NCT02096861). We performed a multivariate logistic analysis to demonstrate the association between early infliximab trough… read more here.
Keywords: trough levels; infliximab; infliximab trough; week ... See more keywords