Influence of glycan modification on IgG1 biochemical and biophysical properties
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2017.12.061
Abstract: Graphical abstract Figure. No caption available. HighlightsGlycosylation affects both physico‐chemical properties of mAbs and their interactions with the key receptors.Fully deglycosylated, hypergalactosylated and hypersialylated mAb molecules were produced and characterized.Aggregation propensity is not increased for… read more here.
Keywords: igg1; influence glycan; ggr; hypergalactosylated hypersialylated ... See more keywords
Influence of glycan structure on the colonization of Streptococcus pneumoniae on human respiratory epithelial cells.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2213584120
Abstract: Virtually all living cells are encased in glycans. They perform key cellular functions such as immunomodulation and cell-cell recognition. Yet, how their composition and configuration affect their functions remains enigmatic. Here, we constructed isogenic capsule-switch… read more here.
Keywords: colonization; influence glycan; epithelial cells; respiratory ... See more keywords