Influence of Trp-Cage on the Function and Stability of GLP-1R Agonist Exenatide Derivatives
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.4c01553
Abstract: Exenatide (Ex4), a GLP-1 incretin mimetic polypeptide, is an effective therapeutic agent against diabetes and obesity. We highlight the indirect role of Ex4’s structure-stabilizing Trp-cage (Tc) motif in governing GLP-1 receptor (GLP-1R) signal transduction. We… read more here.
Keywords: influence trp; stability; trp cage; function stability ... See more keywords