Cosolvent Dimethyl Sulfoxide Influences Protein–Ligand Binding Kinetics via Solvent Viscosity Effects: Revealing the Success Rate of Complex Formation Following Diffusive Protein–Ligand Encounter
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DOI: 10.1021/acs.biochem.2c00507
Abstract: Protein–ligand-exchange kinetics determines the duration of biochemical signals and consequently plays an important role in drug design. Binding studies commonly require solubilization of designed ligands in solvents such as dimethyl sulfoxide (DMSO), resulting in residual… read more here.
Keywords: ligand binding; viscosity; rate; dimethyl sulfoxide ... See more keywords
The influences of palindromes in mRNA on protein folding rates.
Sign Up to like & getrecommendations! Published in 2019 at "Protein and peptide letters"
DOI: 10.2174/0929866526666191014144015
Abstract: BACKGROUND It is currently believed that protein folding rates are influenced by protein structure, environment and temperature, amino acid sequence and so on. We have been working for long to determine whether and in what… read more here.
Keywords: influences protein; palindromes important; folding rates; influences palindromes ... See more keywords