Influenza Hemagglutinin Protein Stability, Activation, and Pandemic Risk.
Sign Up to like & getrecommendations! Published in 2018 at "Trends in microbiology"
DOI: 10.1016/j.tim.2018.03.005
Abstract: For decades, hemagglutinin (HA) protein structure and its refolding mechanism have served as a paradigm for understanding protein-mediated membrane fusion. HA trimers are in a high-energy state and are functionally activated by low pH. Over… read more here.
Keywords: protein; stability activation; influenza hemagglutinin; hemagglutinin protein ... See more keywords
Genetic and subunit vaccines based on the stem domain of the equine influenza hemagglutinin provide homosubtypic protection against heterologous strains.
Sign Up to like & getrecommendations! Published in 2018 at "Vaccine"
DOI: 10.1016/j.vaccine.2018.02.019
Abstract: H3N8 influenza virus strains have been associated with infectious disease in equine populations throughout the world. Although current vaccines for equine influenza stimulate a protective humoral immune response against the surface glycoproteins, disease in vaccinated… read more here.
Keywords: protection; equine influenza; influenza hemagglutinin; influenza ... See more keywords
High-Speed AFM Reveals Molecular Dynamics of Human Influenza A Hemagglutinin and Its Interaction with Exosomes.
Sign Up to like & getrecommendations! Published in 2020 at "Nano letters"
DOI: 10.1021/acs.nanolett.0c01755
Abstract: Influenza A hemagglutinin (HA) is one of the crucial virulence factors that mediate host tropism and viral infectivity. Presently, the mechanism of the fusogenic transition of HA remains elusive. Here, we used high-speed atomic force… read more here.
Keywords: molecular dynamics; influenza hemagglutinin; interaction exosomes; interaction ... See more keywords
Elimination of receptor binding by influenza hemagglutinin improves vaccine-induced immunity
Sign Up to like & getrecommendations! Published in 2022 at "npj Vaccines"
DOI: 10.1038/s41541-022-00463-3
Abstract: The binding of influenza hemagglutinin (HA) to sialic acid (SA) receptors plays a well-defined role in shaping infection but the impact of such binding on vaccine responses has not yet been explored. We generated a… read more here.
Keywords: influenza hemagglutinin; binding influenza; receptor; y98f vlp ... See more keywords
Affinity maturation in a human humoral response to influenza hemagglutinin
Sign Up to like & getrecommendations! Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1915620116
Abstract: Significance Influenza virus and some other human pathogens evolve to evade herd immunity and, hence, to reinfect previously immune individuals. Individual humoral immune responses also evolve, through somatic mutation and selection in a process known… read more here.
Keywords: influenza hemagglutinin; affinity maturation; response; affinity ... See more keywords
Conserved Influenza Hemagglutinin, Neuraminidase and Matrix Peptides Adjuvanted with ALFQ Induce Broadly Neutralizing Antibodies
Sign Up to like & getrecommendations! Published in 2021 at "Vaccines"
DOI: 10.3390/vaccines9070698
Abstract: A universal influenza candidate vaccine that targets multiple conserved influenza virus epitopes from hemagglutinin (HA), neuraminidase (NA) and matrix (M2e) proteins was combined with the potent Army liposomal adjuvant (ALFQ) to promote induction of broad… read more here.
Keywords: matrix peptides; hemagglutinin neuraminidase; influenza hemagglutinin; neuraminidase matrix ... See more keywords