Interferon Gamma-Mediated Oxidative Stress Induces Apoptosis, Neuroinflammation, Zinc Ion Influx, and TRPM2 Channel Activation in Neuronal Cell Line: Modulator Role of Curcumin.
Sign Up to like & getrecommendations! Published in 2021 at "Inflammation"
DOI: 10.1007/s10753-021-01465-4
Abstract: Host defenses in the brain are modulated by the activation of several factors such as oxygen free radical species (ROS), Ca2+ influx, and TRPM2 activation, and they are well-known adverse factors in neurotoxicity and neurodegenerative… read more here.
Keywords: influx; neuroinflammation; trpm2; activation ... See more keywords
Influence of environmentally relevant concentrations of Zn, Cd and Ni and their binary mixtures on metal uptake, bioaccumulation and development in larvae of the purple sea urchin Strongylocentrotus purpuratus.
Sign Up to like & getrecommendations! Published in 2020 at "Aquatic toxicology"
DOI: 10.1016/j.aquatox.2020.105709
Abstract: Metal accumulation, disturbance of Ca2+ homeostasis, and occurrence of abnormalities are well-established consequences of single metal exposure during early development stages of sea urchins. However, the effects caused by low concentrations of metals and metal… read more here.
Keywords: binary mixtures; metal; sea urchin; influx ... See more keywords
The steroid hormone 20-hydroxyecdysone upregulates calcium release-activated calcium channel modulator 1 expression to induce apoptosis in the midgut of Helicoverpa armigera.
Sign Up to like & getrecommendations! Published in 2017 at "Cell calcium"
DOI: 10.1016/j.ceca.2017.10.004
Abstract: Animal steroid hormones stimulate extracellular Ca2+ influx into cells; however, the mechanism remains unclear. In this study, we determined that the Ca2+ influx induced by steroid hormone 20-hydroxyecdysone (20E) is mediated by the calcium release-activated… read more here.
Keywords: steroid hormone; apoptosis; ca2 influx; calcium ... See more keywords
Identification of a Novel Small Molecule That Enhances the Release of Extracellular Vesicles with Immunostimulatory Potency via Induction of Calcium Influx
Sign Up to like & getrecommendations! Published in 2023 at "ACS Chemical Biology"
DOI: 10.1021/acschembio.3c00134
Abstract: Extracellular vesicles (EVs) transfer antigens and immunomodulatory molecules in immunologic synapses as a part of intracellular communication, and EVs equipped with immunostimulatory functions have been utilized for vaccine formulation. Hence, we sought small-molecule compounds that… read more here.
Keywords: influx; small molecule; molecule; induction ... See more keywords
Biological sex does not predict glymphatic influx in healthy young, middle aged or old mice
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-72621-3
Abstract: Sexual dimorphism is evident in brain structure, size, and function throughout multiple species. Here, we tested whether cerebrospinal fluid entry into the glymphatic system, a network of perivascular fluid transport that clears metabolic waste from… read more here.
Keywords: biological sex; middle aged; mice; influx ... See more keywords
Exploiting the protein corona: coating of black phosphorus nanosheets enables macrophage polarization via calcium influx.
Sign Up to like & getrecommendations! Published in 2020 at "Nanoscale"
DOI: 10.1039/c9nr08570j
Abstract: Black phosphorus nanosheets (BPNSs) have substantially promoted biomedical nanotechnology due to their unique photothermal and chemotherapeutic properties. However, there is still a limited molecular understanding of the effects of bio-nano interfaces on BPNSs and the… read more here.
Keywords: corona; polarization; phosphorus nanosheets; phosphorus ... See more keywords
Induction of retinal‐dependent calcium influx in human melanocytes by UVA or UVB radiation contributes to the stimulation of melanosome transfer
Sign Up to like & getrecommendations! Published in 2017 at "Cell Proliferation"
DOI: 10.1111/cpr.12372
Abstract: The transfer of melanosomes from melanocytes to neighbouring keratinocytes is critical to protect the skin from the deleterious effects of ultraviolet A (UVA) and ultraviolet B (UVB) irradiation; however, the initial factor(s) that stimulates melanosome… read more here.
Keywords: dependent calcium; retinal dependent; melanosome transfer; transfer ... See more keywords
Stem cell factor/mast cell/CCL2/monocyte/macrophage axis promotes Coxsackievirus B3 myocarditis and cardiac fibrosis by increasing Ly6Chigh monocyte influx and fibrogenic mediators production
Sign Up to like & getrecommendations! Published in 2022 at "Immunology"
DOI: 10.1111/imm.13556
Abstract: Mast cells (MCs), central players in allergy and parasitic infections, play key roles in inflammation and fibrosis. Here, the impact of MCs on the progression of Coxsackievirus B3 (CVB3)‐induced viral myocarditis (VMC) and fibrosis was… read more here.
Keywords: influx; cell; monocyte; cardiac fibrosis ... See more keywords
RIP3 Contributes to Cardiac Hypertrophy by Influencing MLKL-Mediated Calcium Influx
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/5490553
Abstract: Receptor-interacting protein 3(RIP3), a RIP family member, has been reported as a critical regulator of necroptosis and involves in the pathogenesis of various heart diseases. However, its role in the development of myocardial hypertrophy after… read more here.
Keywords: influx; myocardial hypertrophy; calcium; hypertrophy ... See more keywords
Imaging and Analysis of Presynaptic Calcium Influx in Cultured Neurons Using synGCaMP6f
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Synaptic Neuroscience"
DOI: 10.3389/fnsyn.2019.00012
Abstract: Presynaptic Ca2+ influx through voltage-gated calcium channels (VGCCs) is a key step in synaptic transmission that links action potential (AP)-derived depolarization to vesicle release. However, investigation of presynaptic Ca2+ influx by patch clamp recordings is… read more here.
Keywords: ca2 transients; presynaptic calcium; presynaptic ca2; ca2 ... See more keywords
Extracellular Calcium Influx Pathways in Astrocyte Calcium Microdomain Physiology
Sign Up to like & getrecommendations! Published in 2021 at "Biomolecules"
DOI: 10.3390/biom11101467
Abstract: Astrocytes are complex glial cells that play many essential roles in the brain, including the fine-tuning of synaptic activity and blood flow. These roles are linked to fluctuations in intracellular Ca2+ within astrocytes. Recent advances… read more here.
Keywords: microdomain; extracellular calcium; physiology; ca2 ... See more keywords