Bayesian methods for the analysis of early-phase oncology basket trials with information borrowing across cancer types.
Sign Up to like & getrecommendations! Published in 2020 at "Statistics in medicine"
DOI: 10.1002/sim.8675
Abstract: Research in oncology has changed the focus from histological properties of tumors in a specific organ to a specific genomic aberration potentially shared by multiple cancer types. This motivates the basket trial, which assesses the… read more here.
Keywords: cancer; cancer types; oncology; information borrowing ... See more keywords
Use of pharmacodynamic modeling for Bayesian information borrowing in pediatric clinical trials.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of biopharmaceutical statistics"
DOI: 10.1080/10543406.2022.2149772
Abstract: The use of Bayesian methodology to design and analyze pediatric efficacy trials is one of the possible options to reduce their sample size. This reduction of the sample size results from the use of an… read more here.
Keywords: efficacy; information borrowing; informative prior; pharmacodynamic modeling ... See more keywords