Model‐Informed Drug Development for Antimicrobials: Translational PK and PK/PD Modeling to Predict an Efficacious Human Dose for Apramycin
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DOI: 10.1002/cpt.2104
Abstract: Apramycin represents a subclass of aminoglycoside antibiotics that has been shown to evade almost all mechanisms of clinically relevant aminoglycoside resistance. Model‐informed drug development may facilitate its transition from preclinical to clinical phase. This study… read more here.
Keywords: model informed; model; informed drug; dose ... See more keywords
Model‐informed drug repurposing: A pharmacometric approach to novel pathogen preparedness, response and retrospection
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DOI: 10.1111/bcp.14760
Abstract: During a pandemic caused by a novel pathogen (NP), drug repurposing offers the potential of a rapid treatment response via a repurposed drug (RD) while more targeted treatments are developed. Five steps of model‐informed drug… read more here.
Keywords: novel pathogen; drug repurposing; model informed; drug ... See more keywords
Model Informed Drug Development: Novel Oncology Agents are Lost in Translation
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DOI: 10.1158/1078-0432.ccr-19-2482
Abstract: Excitement around and investment in oncology drug development are at unprecedented levels. To maximize the health impact and productivity of this research and development investment, quantitative modeling should impact key decisions in early clinical oncology… read more here.
Keywords: informed drug; development; drug development; oncology ... See more keywords