NO-Dependent LTD in Infralimbic L5 Neurons.
Sign Up to like & getrecommendations! Published in 2019 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2019.08.029
Abstract: Dendritic calcium (Ca2+) spikes play a key role in the genesis of long-term synaptic plasticity. Although synaptic plasticity in the infralimbic cortex is critical for the extinction of fear conditioned memory, the role of Ca2+-spikes… read more here.
Keywords: ca2 spikes; synaptic plasticity; plasticity; infralimbic cortex ... See more keywords
Infralimbic cortex is required for learning alternatives to prelimbic promoted associations through reciprocal connectivity
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-05318-x
Abstract: Prefrontal cortical areas mediate flexible adaptive control of behavior, but the specific contributions of individual areas and the circuit mechanisms through which they interact to modulate learning have remained poorly understood. Using viral tracing and… read more here.
Keywords: reciprocal connectivity; connectivity; reciprocal prel; prel ... See more keywords
Fos‐expressing neuronal ensembles in rat infralimbic cortex encode initial and maintained oxycodone seeking in rats
Sign Up to like & getrecommendations! Published in 2022 at "Addiction Biology"
DOI: 10.1111/adb.13148
Abstract: Neuronal ensembles within the infralimbic cortex (IL) and their projections to the nucleus accumbens (NAc) mediate opiate seeking in well‐trained rats. However, it is unclear how early this circuitry is recruited during oxycodone self‐administration. Here,… read more here.
Keywords: self administration; neuronal ensembles; infralimbic cortex; oxycodone self ... See more keywords
Blockade of orexin receptors in the infralimbic cortex prevents stress‐induced reinstatement of alcohol‐seeking behaviour in alcohol‐dependent rats
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Pharmacology"
DOI: 10.1111/bph.16015
Abstract: A major problem managing alcohol use disorder is the high vulnerability to relapse, even after long periods of abstinence. Chronic alcohol use dysregulates stress responsivity, rendering this system hyporesponsive and making individuals vulnerable to relapse.… read more here.
Keywords: infralimbic cortex; induced reinstatement; stress induced; alcohol ... See more keywords
mTOR Knockdown in the Infralimbic Cortex Evokes A Depressive-like State in Mouse
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22168671
Abstract: Fast and sustained antidepressant effects of ketamine identified the mammalian target of rapamycin (mTOR) signaling pathway as the main modulator of its antidepressive effects. Thus, mTOR signaling has become integral for the preclinical evaluation of… read more here.
Keywords: depressive like; mtor; mtor knockdown; knockdown infralimbic ... See more keywords