The intact nephron hypothesis as a model for renal drug handling
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Clinical Pharmacology"
DOI: 10.1007/s00228-018-2572-8
Abstract: PurposeThe intact nephron hypothesis (INH) states that impaired renal function results from a reduction in the number of complete (intact) nephrons. Under this model, renal drug clearance is assumed to be a linear function of… read more here.
Keywords: inh; renal drug; drug; intact nephron ... See more keywords
Treatment of Hereditary Angioedema Attacks with Icatibant and Recombinant C1 Inhibitor During Pregnancy
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Immunology"
DOI: 10.1007/s10875-018-0553-4
Abstract: PurposeHereditary angioedema (HAE) is a rare disease caused by a C1 inhibitor (C1-INH) deficit. Clinically, HAE is manifested by repeated episodes of localized subcutaneous or submucosal oedema attacks. Managing HAE patients in pregnancy is challenging,… read more here.
Keywords: inh; pregnancy; inhibitor; treatment ... See more keywords
On irreducible no-hole L(2, 1)-coloring of subdivision of graphs
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Combinatorial Optimization"
DOI: 10.1007/s10878-016-0047-3
Abstract: An L(2, 1)-coloring (or labeling) of a graph G is a mapping $$f:V(G) \rightarrow \mathbb {Z}^{+}\bigcup \{0\}$$f:V(G)→Z+⋃{0} such that $$|f(u)-f(v)|\ge 2$$|f(u)-f(v)|≥2 for all edges uv of G, and $$|f(u)-f(v)|\ge 1$$|f(u)-f(v)|≥1 if u and v are at… read more here.
Keywords: hole coloring; span; inh; irreducible hole ... See more keywords
Anti-tuberculosis site-specific oral delivery system that enhances rifampicin bioavailability in a fixed-dose combination with isoniazid.
Sign Up to like & getrecommendations! Published in 2020 at "Drug delivery and translational research"
DOI: 10.1007/s13346-020-00847-9
Abstract: The in vivo release segregation of rifampicin (RIF) and isoniazid (INH) has been proposed as a strategy to avoid RIF acid degradation, which is known as one of the main factors for reduced RIF bioavailability… read more here.
Keywords: inh; bioavailability; delivery; tuberculosis ... See more keywords
TRANSBUCCAL DELIVERY OF METAL COMPLEXES OF ISONIAZID AS AN ALTERNATIVE TO OVERCOME ANTIMICROBIAL RESISTANCE PROBLEMS.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2020.119924
Abstract: In isolated isoniazid(INH)-resistant strains, deletion or mutations in thekatGgene have been identified, which result in loss of catalase-peroxidase activity. This enzyme plays a key role in the activation of this prodrug. As an alternative, the… read more here.
Keywords: inh; delivery; metal; metal complexes ... See more keywords
Therapeutic effect of an anti-tuberculosis agent, isoniazid, and its nano-isoform in ulcerative colitis.
Sign Up to like & getrecommendations! Published in 2021 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2021.107577
Abstract: BACKGROUND Isoniazid (INH) is well known as a first-line anti-tuberculosis, while some studies demonstrate that it has anti-inflammatory activity via a different mechanism such as inhibitionthe production of IL-1, ROS, activation of PPARγ expression, inhibition… read more here.
Keywords: inh; therapeutic effect; colitis; ulcerative colitis ... See more keywords
Isoniazid acetylation phenotypes in the Sudanese population; findings and implications
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Tuberculosis and Other Mycobacterial Diseases"
DOI: 10.1016/j.jctube.2019.100120
Abstract: Background Isoniazid (INH) is the mainstay antimicrobial in the treatment of tuberculosis (TB). It is acetlylated in the liver to acetyl-INH. However, there is variation in rate of acetylation of INH among TB patients (i.e.… read more here.
Keywords: inh; acetylation; acetylation phenotypes; sudanese population ... See more keywords
Inconsistencies of e-waste management in developing nations - Facts and plausible solutions.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of environmental management"
DOI: 10.1016/j.jenvman.2020.110234
Abstract: Electronic and electrical equipment (EEE) became an integral part of daily life and had an immense influence on the economy. The skyrocketing demand, progressive technologies, and high dependency resulted in inconceivable utilization of EEE. However,… read more here.
Keywords: inh; waste management; management; management developing ... See more keywords
Reinvestigation of the structure-activity relationships of isoniazid.
Sign Up to like & getrecommendations! Published in 2021 at "Tuberculosis"
DOI: 10.1016/j.tube.2021.102100
Abstract: Isoniazid (INH) remains a cornerstone for treatment of drug susceptible tuberculosis (TB), yet the quantitative structure-activity relationships for INH are not well documented in the literature. In this paper, we have evaluated a systematic series… read more here.
Keywords: inh; activity relationships; inh analogs; structure activity ... See more keywords
Potential to Use Fingerprints for Monitoring Therapeutic Levels of Isoniazid and Treatment Adherence
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c01257
Abstract: A fingerprint offers a convenient, noninvasive sampling matrix for monitoring therapeutic drug use. However, a barrier to widespread adoption of fingerprint sampling is the fact that the sample volume is uncontrolled. Fingerprint samples (n =… read more here.
Keywords: fingerprint; sample volume; treatment; monitoring therapeutic ... See more keywords
α1-Antichymotrypsin Present in Therapeutic C1-Inhibitor Products Competes with Selectin-Sialyl LewisX Interaction.
Sign Up to like & getrecommendations! Published in 2018 at "Thrombosis and haemostasis"
DOI: 10.1055/s-0038-1675601
Abstract: BACKGROUND C1-inhibitor (C1-inh) therapeutics can reduce neutrophil activity in various inflammatory conditions. This 'novel' anti-inflammatory effect of C1-inh is attributed to the tetrasaccharide sialyl LewisX (SLeX) present on its N-glycans. Via SLeX, C1-inh is suggested… read more here.
Keywords: inh; inhibitor; act; antichymotrypsin ... See more keywords