862: LOWER RESPIRATORY TRACT DELIVERY, AIRWAY CLEARANCE, AND PRECLINICAL EFFICACY OF INHALED GM-CSF
Sign Up to like & getrecommendations! Published in 2020 at "Critical Care Medicine"
DOI: 10.1097/01.ccm.0000631584.50010.e3
Abstract: Introduction/Hypothesis: Inhaled GM-CSF shows promise as a therapeutic to treat viral and bacterial pneumonia, but to date, no mouse model of inhaled GM-CSF has been described. We sought to: 1) develop a mouse model of… read more here.
Keywords: csf; inhaled csf; respiratory tract; mouse ... See more keywords
Inhaled GM-CSF in neonatal mice provides durable protection against bacterial pneumonia
Sign Up to like & getrecommendations! Published in 2019 at "Science Advances"
DOI: 10.1126/sciadv.aax3387
Abstract: A different route of administering GM-CSF may selectively manipulate tissue-resident macrophages to therapeutic benefit. Pneumonia poses profound health threats to preterm infants. Alveolar macrophages (AMs) eliminate inhaled pathogens while maintaining surfactant homeostasis. As AM development… read more here.
Keywords: inhaled csf; bacterial pneumonia; neonatal mice; csf neonatal ... See more keywords