In vitro, ex vivo and in vivo methods of lung absorption for inhaled drugs.
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DOI: 10.1016/j.addr.2020.07.025
Abstract: The assessment and prediction of lung absorption and disposition are an increasingly essential preclinical task for successful discovery and product development of inhaled drugs for both local and systemic delivery. Hence, in vitro, ex vivo… read more here.
Keywords: absorption; vitro vivo; inhaled drugs; vivo vivo ... See more keywords
Developing inhaled drugs for respiratory diseases: a medicinal chemistry perspective.
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DOI: 10.1016/j.drudis.2021.09.005
Abstract: Despite the devastating impact of many lung diseases on human health, there is still a significant unmet medical need in respiratory diseases, for which inhaled delivery represents a crucial strategy. More guidance on how to… read more here.
Keywords: developing inhaled; medicinal chemistry; chemistry; inhaled drugs ... See more keywords
A mechanistic framework for a priori pharmacokinetic predictions of orally inhaled drugs
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DOI: 10.1371/journal.pcbi.1008466
Abstract: The fate of orally inhaled drugs is determined by pulmonary pharmacokinetic processes such as particle deposition, pulmonary drug dissolution, and mucociliary clearance. Even though each single process has been systematically investigated, a quantitative understanding on… read more here.
Keywords: framework; mechanistic model; drug; inhaled drugs ... See more keywords