Inherited polygenic effects on common hematological traits influence clonal selection on JAK2V617F and the development of myeloproliferative neoplasms
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DOI: 10.1038/s41588-023-01638-x
Abstract: Myeloproliferative neoplasms (MPNs) are chronic cancers characterized by overproduction of mature blood cells. Their causative somatic mutations, for example, JAK2V617F, are common in the population, yet only a minority of carriers develop MPN. Here we… read more here.
Keywords: traits influence; common hematological; myeloproliferative neoplasms; inherited polygenic ... See more keywords