Bank vole prion protein extends the use of RT-QuIC assays to detect prions in a range of inherited prion diseases
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-84527-9
Abstract: The cerebrospinal fluid (CSF) real-time quaking-induced conversion assay (RT-QuIC) is an ultrasensitive prion amyloid seeding assay for diagnosis of sporadic Creutzfeldt–Jakob disease (CJD) but several prion strains remain unexplored or resistant to conversion with commonly… read more here.
Keywords: inherited prion; prion; prion protein; bank vole ... See more keywords
Inherited Prion Disease with a 5-octapeptide Repeat Insertion in the PRNP Gene Presenting with Familial Juvenile Dementia
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DOI: 10.2169/internalmedicine.5143-24
Abstract: A 47-year-old man with a family history of juvenile dementia in his mother presented with memory loss and cognitive decline. Neuropsychological tests revealed impaired orientation, working memory, and apraxia. Magnetic resonance imaging revealed diffuse brain… read more here.
Keywords: disease; inherited prion; juvenile dementia; prion disease ... See more keywords