Hepatitis C virus drugs that inhibit SARS-CoV-2 papain-like protease synergize with remdesivir to suppress viral replication in cell culture
Sign Up to like & getrecommendations! Published in 2021 at "Cell Reports"
DOI: 10.1016/j.celrep.2021.109133
Abstract: Effective control of COVID-19 requires antivirals directed against SARS-CoV-2. We assessed ten hepatitis C virus (HCV) protease-inhibitor drugs as potential SARS-CoV-2 antivirals. There is a striking structural similarity of the substrate binding clefts of SARS-CoV-2… read more here.
Keywords: inhibit sars; protease; drugs inhibit; sars cov ... See more keywords
Natural triterpenoids from licorice potently inhibit SARS-CoV-2 infection
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Advanced Research"
DOI: 10.1016/j.jare.2021.11.012
Abstract: Introduction The COVID-19 global epidemic caused by severe acute respiratory syndrome coronavirus (SARS-CoV-2) is a great public health emergency. Discovering antiviral drug candidates is urgent for the prevention and treatment of COVID-19. Objectives This work… read more here.
Keywords: cov infection; sars cov; potently inhibit; triterpenoids licorice ... See more keywords
Both Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-18233-x
Abstract: COVID-19 was declared a pandemic on March 11 by WHO, due to its great threat to global public health. The coronavirus main protease (Mpro, also called 3CLpro) is essential for processing and maturation of the… read more here.
Keywords: inhibit sars; efficaciously inhibit; main protease; gc376 ... See more keywords
Traditional herbal compounds as candidates to inhibit the SARS-CoV-2 main protease: an in silico study
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2021.2023646
Abstract: Abstract COVID-19, a disease caused by the SARS-CoV-2 virus, is responsible for a pandemic since March 2020 and it has no cure. Therefore, herein, different theoretical methods were used to obtain potential candidates from herbal… read more here.
Keywords: cov main; main protease; candidates inhibit; herbal compounds ... See more keywords
Acetylsalicylic Acid and Salicylic Acid Inhibit SARS-CoV-2 Replication in Precision-Cut Lung Slices
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DOI: 10.3390/vaccines10101619
Abstract: Aspirin, with its active compound acetylsalicylic acid (ASA), shows antiviral activity against rhino- and influenza viruses and at high concentrations. We sought to investigate whether ASA and its metabolite salicylic acid (SA) inhibit SARS-CoV-2 since… read more here.
Keywords: acetylsalicylic acid; replication; salicylic acid; acid inhibit ... See more keywords