Novel potent azetidine-based compounds irreversibly inhibit Stat3 activation and induce antitumor response against human breast tumor growth in vivo.
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DOI: 10.1016/j.canlet.2022.215613
Abstract: Signal transducer and activator of transcription (Stat)3 is a valid anticancer therapeutic target. We have discovered a highly potent chemotype that amplifies the Stat3-inhibitory activity of lead compounds to levels previously unseen. The azetidine-based compounds,… read more here.
Keywords: potent azetidine; inhibit stat3; growth; azetidine based ... See more keywords