Articles with "inhibiting autophagy" as a keyword



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Biochanin A Sensitizes Glioblastoma to Temozolomide by Inhibiting Autophagy

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Published in 2022 at "Molecular Neurobiology"

DOI: 10.1007/s12035-021-02674-6

Abstract: Resistance to temozolomide (TMZ) chemotherapy is the main reason for treatment failure in patients with glioblastoma (GBM). In the present study, we investigated biochanin A (BCA) a potent sensitizer of TMZ in GBM. We observed… read more here.

Keywords: temozolomide inhibiting; glioblastoma temozolomide; inhibiting autophagy; sensitizes glioblastoma ... See more keywords
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Synthesis and evaluation of novel benzotropolones as Atg4B inhibiting autophagy blockers.

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Published in 2019 at "Bioorganic chemistry"

DOI: 10.1016/j.bioorg.2019.03.021

Abstract: Autophagy is an intracellular degradation/recycling pathway that provides nutrients and building blocks to cellular metabolism and keeps the cytoplasm clear of obsolete proteins and organelles. During recent years, dysregulated autophagy activity has been reported to… read more here.

Keywords: benzotropolones atg4b; evaluation novel; novel benzotropolones; inhibiting autophagy ... See more keywords
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Inhibiting autophagy before it starts.

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Published in 2023 at "Autophagy"

DOI: 10.1080/15548627.2023.2197364

Abstract: Autophagy, an important cellular stress response mechanism, is often exploited by a variety of cancer cells to sustain rapid growth under stresses such as nutrient deprivation and hypoxia. Autophagy also plays a key role in… read more here.

Keywords: autophagy starts; inhibiting autophagy; transcription factor; autophagy ... See more keywords
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Blockade of ClC-3 enhances cisplatin-sensitivity of cholangiocarcinoma cells though inhibiting autophagy.

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Published in 2022 at "Canadian journal of physiology and pharmacology"

DOI: 10.1139/cjpp-2022-0058

Abstract: Chemotherapy is one of the most important strategies in the treatment of cancer, however, chemo-resistance restricts the effect of chemotherapy. Growing reports suggest that chloride channel-3 (ClC-3) is involved in regulating the sensitivity of multiple… read more here.

Keywords: sensitivity; clc; cisplatin sensitivity; cells though ... See more keywords

LAPTM4B knockdown increases the radiosensitivity of EGFR-overexpressing radioresistant nasopharyngeal cancer cells by inhibiting autophagy

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Published in 2019 at "OncoTargets and therapy"

DOI: 10.2147/ott.s207810

Abstract: Purpose Nasopharyngeal carcinoma (NPC) is a malignant tumor that commonly occurs in southern China and Southeast Asia. Radiation therapy is the main treatment for patients with NPC, and the radioresistance of NPC is an unresolved… read more here.

Keywords: radioresistance; microscopy; egfr laptm4b; npc ... See more keywords