LCZ696 protects against doxorubicin-induced cardiotoxicity by inhibiting ferroptosis via AKT/SIRT3/SOD2 signaling pathway activation.
Sign Up to like & getrecommendations! Published in 2022 at "International immunopharmacology"
DOI: 10.2139/ssrn.4153607
Abstract: Doxorubicin (DOX) is an effective and widely used anticancer drug but has limited clinical applicability because of its cardiotoxicity. Ferroptosis plays a key role in DOX-induced cardiac damage and cardiomyocyte cell death. The inhibition of… read more here.
Keywords: induced cardiotoxicity; lcz696; cardiotoxicity; inhibiting ferroptosis ... See more keywords
Knockdown of ATF3 suppresses the progression of ischemic stroke through inhibiting ferroptosis
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DOI: 10.3389/fnmol.2022.1079338
Abstract: Objective Current therapies towards ischemic stroke (IS) are still not satisfied, and alternative strategies targeting ferroptosis may be another choice. The purpose of this study is to screen potential ferroptosis-related genes involving in IS. Methods… read more here.
Keywords: knockdown atf3; model rats; inhibiting ferroptosis; ferroptosis ... See more keywords
Fisetin Attenuates Doxorubicin-Induced Cardiomyopathy In Vivo and In Vitro by Inhibiting Ferroptosis Through SIRT1/Nrf2 Signaling Pathway Activation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.808480
Abstract: Doxorubicin (DOX) is an anthracycline antibiotic that is used extensively for the management of carcinoma; however, its clinical application is limited due to its serious cardiotoxic side effects. Ferroptosis represents iron-dependent and reactive oxygen species… read more here.
Keywords: dox induced; induced cardiomyopathy; inhibiting ferroptosis; sirt1 ... See more keywords