The p38α Stress Kinase Suppresses Aneuploidy Tolerance by Inhibiting Hif-1α
Sign Up to like & getrecommendations! Published in 2018 at "Cell Reports"
DOI: 10.1016/j.celrep.2018.09.060
Abstract: Summary Deviating from the normal karyotype dramatically changes gene dosage, in turn decreasing the robustness of biological networks. Consequently, aneuploidy is poorly tolerated by normal somatic cells and acts as a barrier to transformation. Paradoxically,… read more here.
Keywords: inhibiting hif; kinase; p38 stress; aneuploidy tolerance ... See more keywords
T2 Factor inhibiting HIF (FIH1) modulates cardiac function and metabolism
Sign Up to like & getrecommendations! Published in 2018 at "Heart"
DOI: 10.1136/heartjnl-2018-bscr.2
Abstract: Hypoxia-inducible factor (HIF) plays a pivotal role in the cellular response to reduced oxygen availability. HIF activity is regulated by two families of oxygen sensitive enzymes; the prolyl hydroxylase domain (PHD) family, and factor-inhibiting HIF… read more here.
Keywords: metabolism; fih1; inhibiting hif; factor inhibiting ... See more keywords
Regulation of Transactivation at C-TAD Domain of HIF-1α by Factor-Inhibiting HIF-1α (FIH-1): A Potential Target for Therapeutic Intervention in Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/2407223
Abstract: Hypoxia-inducible factor-1alpha (HIF-1α) is a major transcription factor that adapts to low oxygen homeostasis and regulates the expression of several hypoxic genes, which aid in cancer survival and development. It has recently piqued the interest… read more here.
Keywords: factor inhibiting; tad domain; hif; factor ... See more keywords