(-)-4-O-(4-O-β-D-glucopyranosylcaffeoyl) quinic acid enhanced the efficacy of anti-PD-L1 against esophageal carcinoma through inhibiting PI3K pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Immunopharmacology and immunotoxicology"
DOI: 10.1080/08923973.2021.1990315
Abstract: PURPOSE Using antibodies to block the programmed cell death 1 (PD-1)/programmed cell death-ligand 1 (PD-L1) pathway as an immunotherapy has achieved great success in the clinical treatment of various types of carcinoma. However, the efficacy… read more here.
Keywords: glucopyranosylcaffeoyl quinic; inhibiting pi3k; quinic acid; efficacy anti ... See more keywords
GLUD1 suppresses renal tumorigenesis and development via inhibiting PI3K/Akt/mTOR pathway
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.975517
Abstract: Growing cancer cells are addicted to glutamine. Glutamate dehydrogenase 1 (GLUD1) is one of key enzymes in glutamine metabolism and plays a critical role in the malignancy of diverse tumors. However, its role and molecular… read more here.
Keywords: inhibiting pi3k; pi3k akt; ccrcc; glud1 level ... See more keywords