Cyclooxygenase-Inhibiting Platinum(IV) Prodrugs with Potent Anticancer Activity
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DOI: 10.3390/pharmaceutics14040787
Abstract: Platinum(IV) prodrugs of the [Pt(PL)(AL)(COXi)(OH)]2+ type scaffold (where PL is 1,10-phenanthroline or 5,6-dimethyl-1,10-phenanthroline, AL is 1S,2S-diaminocyclohexane, and COXi is a COX inhibitor, either indomethacin or aspirin) were synthesised and characterised, and their biological activity was… read more here.
Keywords: cyclooxygenase inhibiting; inhibiting platinum; platinum prodrugs; activity ... See more keywords