Inhibition of Aggregation in B-Sheet Model Peptide by PPII Helix Capping
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.316
Abstract: A 12mer peptide (Beta, SWTVEGNKYTYK-NH2) was designed based on the Trpzip model. Beta can form an aggregate with fibril like morphology imaged by TEM. The secondary structure of the fibril was characterized to be anti-parallel… read more here.
Keywords: aggregation; inhibition aggregation; beta; model ... See more keywords
Neutrophil Granule Proteins Inhibit Amyloid Beta Aggregation and Neurotoxicity.
Sign Up to like & getrecommendations! Published in 2021 at "Current Alzheimer research"
DOI: 10.2174/1567205018666210823095044
Abstract: BACKGROUND A role for neutrophils in the pathogenesis of Alzheimer's disease (AD) is emerging. We previously showed that the neutrophil granule proteins cationic antimicrobial protein of 37 kDa (CAP37), cathepsin G (CG), and neutrophil elastase… read more here.
Keywords: neutrophil granule; aggregation; inhibition aggregation; amyloid beta ... See more keywords