Inhibition of alpha-synuclein aggregation by AM17, a synthetic resveratrol derivative.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.08.049
Abstract: Parkinson's disease (PD) is linked to the aberrant self-assembly of the amyloid protein, α-synuclein (αS), where αS monomers aggregate to form oligomers and fibrils. Out of the three conformers, αS oligomers are the major toxic… read more here.
Keywords: synuclein aggregation; aggregation; resveratrol; inhibition alpha ... See more keywords
Insights Into Peptide Inhibition of Alpha-Synuclein Aggregation
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2020.561462
Abstract: α-Synuclein (aSyn) aggregation is an attractive target for therapeutic development for a range of neurodegenerative conditions, collectively termed synucleinopathies. Here, we probe the mechanism of action of a peptide 4554W, (KDGIVNGVKA), previously identified through intracellular… read more here.
Keywords: peptide inhibition; aggregation; synuclein; inhibition alpha ... See more keywords