Inhibition of Amyloid Protein Aggregation Using Selected Peptidomimetics
Sign Up to like & getrecommendations! Published in 2022 at "ChemMedChem"
DOI: 10.1002/cmdc.202200499
Abstract: Aberrant protein aggregation leads to the formation of amyloid fibrils. This phenomenon is linked to the development of more than 40 irremediable diseases such as Alzheimer's disease, Parkinson's disease, type 2 diabetes, and cancer. Plenty… read more here.
Keywords: aggregation; inhibition amyloid; amyloid protein; protein aggregation ... See more keywords
Review on Alzheimer's disease: Inhibition of amyloid beta and tau tangle formation.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.11.192
Abstract: It is reported that approximately 40 million people are suffering from dementia, globally. Dementia is a group of symptoms that affect neurons and cause some mental disorders, such as losing memory. Alzheimer's disease (AD) which… read more here.
Keywords: inhibition amyloid; alzheimer disease; amyloid beta; formation ... See more keywords
Inhibition of amyloid fibrillation of γD-crystallin model peptide by the cochineal Carmine.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.12.106
Abstract: γD-crystallin is among the most abundant γ-crystallins in the human eye lens which are essential for preserving its transparency. Aging, and environmental changes, cause crystallins to lose their native soluble structure and aggregate, resulting in… read more here.
Keywords: amyloid fibrillation; inhibition amyloid; model; cochineal carmine ... See more keywords
Functional bioprobe for responsive imaging and inhibition of amyloid-β oligomer based on curcuminoid scaffold
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Luminescence"
DOI: 10.1016/j.jlumin.2021.118218
Abstract: Abstract Alzheimer's Disease (AD) is a type of neural disease, which is characterized by behavioural disorder and progressive loss of cognitive function. Since there are no obvious symptoms of early-stage AD, it is difficult to… read more here.
Keywords: functional bioprobe; bioprobe responsive; responsive imaging; imaging inhibition ... See more keywords
Inhibition of β-Amyloid Aggregation in Alzheimer’s Disease: The Key Role of (Pro)electrophilic Warheads
Sign Up to like & getrecommendations! Published in 2022 at "ACS Medicinal Chemistry Letters"
DOI: 10.1021/acsmedchemlett.2c00410
Abstract: Catechols have been largely investigated as antiaggregating agents toward β-amyloid peptide. Herein, as a follow up of a previous series of hydroxycinnamic derivatives, we synthesized a small set of dihydroxy isomers for exploring the role… read more here.
Keywords: inhibition amyloid; role; alzheimer disease; aggregation alzheimer ... See more keywords
Inhibition of amyloid Aβ aggregation by high pressures or specific d-enantiomeric peptides.
Sign Up to like & getrecommendations! Published in 2018 at "Chemical communications"
DOI: 10.1039/c8cc01458b
Abstract: Pressure can shift the polymer-monomer equilibrium of Aβ, increasing pressure first leads to a release of Aβ-monomers, surprisingly at pressures higher than 180 MPa repolymerization is induced. By high pressure NMR spectroscopy, differences of partial… read more here.
Keywords: pressure; aggregation high; inhibition amyloid; high pressures ... See more keywords
Inhibition of amyloid fibril formation of β-lactoglobulin by natural and synthetic curcuminoids
Sign Up to like & getrecommendations! Published in 2018 at "New Journal of Chemistry"
DOI: 10.1039/c8nj03194k
Abstract: The aggregation of proteins has been associated with several aspects of daily life, including food processing, blood coagulation and many neurodegenerative infections. However, the actual mechanisms responsible for amyloidosis, the irreversible fibril formation of various… read more here.
Keywords: inhibition amyloid; formation; fibril formation; amyloid fibril ... See more keywords
Inhibition of Amyloid Fibrillation by Small Molecules and Nanomaterials: Strategic Development of Pharmaceuticals Against Amyloidosis.
Sign Up to like & getrecommendations! Published in 2019 at "Protein and peptide letters"
DOI: 10.2174/0929866526666190307164944
Abstract: Amyloid fibrils are a special class of self-assembled protein molecules, which exhibit various toxic effects in cells. Different physiological disorders such as Alzheimer's, Parkinson's, Huntington's diseases, etc. happen due to amyloid formation and lack of… read more here.
Keywords: amyloid fibrillation; small molecules; development; inhibition amyloid ... See more keywords