Inhibition of antiapoptotic BCL-2 proteins with ABT-263 induces fibroblast apoptosis, reversing persistent pulmonary fibrosis
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DOI: 10.1172/jci.insight.163762
Abstract: Patients with progressive fibrosing interstitial lung diseases (PF-ILDs) carry a poor prognosis and have limited therapeutic options. A hallmark feature is fibroblast resistance to apoptosis, leading to their persistence, accumulation, and excessive deposition of extracellular… read more here.
Keywords: antiapoptotic bcl; abt 263; apoptosis; inhibition antiapoptotic ... See more keywords