Evaluation of herb-drug interaction of a polyherbal Ayurvedic formulation through high throughput cytochrome P450 enzyme inhibition assay.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2016.07.061
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Arishtas are Ayurvedic formulation made with decoction of herbs. Arjunarishta formulation is being used in Ayurveda for cardio-protective activity. Ashwagandharishta formulation possesses antioxidant, anti-atherosclerotic and anti-stress properties. Ridayarishta, a novel empirical formulation was… read more here.
Keywords: enzyme inhibition; inhibition; formulation; inhibition assay ... See more keywords
Investigations into the Antibacterial Mechanism of Action of Viridicatumtoxins.
Sign Up to like & getrecommendations! Published in 2020 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.0c00031
Abstract: Viridicatumtoxins are a rare class of tetracycline-like antibiotics that strongly inhibit drug-resistant Gram-positive bacteria. Although reported to exhibit in vitro inhibition activity to undecaprenyl pyrophosphate synthase (UPPS), an essential enzyme in bacterial cell wall synthesis,… read more here.
Keywords: inhibition assay; inhibition; vira virb; action viridicatumtoxins ... See more keywords
A fucosyltransferase inhibition assay using image-analysis and digital microfluidics.
Sign Up to like & getrecommendations! Published in 2019 at "Biomicrofluidics"
DOI: 10.1063/1.5088517
Abstract: Sialyl-LewisX and LewisX are cell-surface glycans that influence cell-cell adhesion behaviors. These glycans are assembled by α(1,3)-fucosyltransferase enzymes. Their increased expression plays a role in inflammatory disease, viral and microbial infections, and cancer. Efficient screens… read more here.
Keywords: analysis digital; image; inhibition assay; inhibition ... See more keywords
Investigation of the Fuzzy Complex between RSV Nucleoprotein and Phosphoprotein to Optimize an Inhibition Assay by Fluorescence Polarization
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24010569
Abstract: The interaction between Respiratory Syncytial Virus phosphoprotein P and nucleoprotein N is essential for the formation of the holo RSV polymerase that carries out replication. In vitro screening of antivirals targeting the N-P protein interaction… read more here.
Keywords: phosphoprotein; inhibition; inhibition assay; rsv ... See more keywords
Discovery of Novel Thiazolidinedione-Derivatives with Multi-Modal Antidiabetic Activities In Vitro and In Silico
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24033024
Abstract: Diabetes mellitus (DM) and related complications continue to exert a significant burden on health care systems globally. Although conventional pharmacological therapies are beneficial in the management of this metabolic condition, it is still necessary to… read more here.
Keywords: inhibition; novel thiazolidinedione; inhibition assay; activity ... See more keywords