UCHL1 inhibition attenuates cardiac fibrosis via modulation of nuclear factor-κB signaling in fibroblasts.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2021.174045
Abstract: The ubiquitin-proteasome system (UPS) plays an essential role in cellular homeostasis and myocardial function. Ubiquitin carboxy-terminal hydrolase 1 (UCHL1) is involved in cardiac remodeling, but its underlying mechanisms are largely unknown. Here, we observed that… read more here.
Keywords: fibrosis; cardiac fibrosis; inhibition attenuates; nuclear factor ... See more keywords
Kv1.3 inhibition attenuates neuroinflammation through disruption of microglial calcium signaling
Sign Up to like & getrecommendations! Published in 2021 at "Channels"
DOI: 10.1080/19336950.2020.1853943
Abstract: ABSTRACT In the last 5 years inhibitors of the potassium channel KV1.3 have been shown to reduce neuroinflammation in rodent models of ischemic stroke, Alzheimer’s disease, Parkinson’s disease and traumatic brain injury. At the systemic… read more here.
Keywords: inhibition attenuates; kv1 inhibition; disruption microglial; calcium ... See more keywords
STAT3 Inhibition Attenuates MYC Expression by Modulating Co-Activator Recruitment and Suppresses Medulloblastoma Tumor Growth by Augmenting Cisplatin Efficacy In Vivo
Sign Up to like & getrecommendations! Published in 2023 at "Cancers"
DOI: 10.3390/cancers15082239
Abstract: Simple Summary Medulloblastoma (MB) is a malignant brain tumor of childhood that occurs in the cerebellum and accounts for 20–25% of all pediatric central nervous system tumors. Despite improvement in overall survival rate, it still… read more here.
Keywords: stat3 inhibition; expression; efficacy; inhibition attenuates ... See more keywords