Prospects for PLD Inhibition in Cancer and Thrombotic Disease.
Sign Up to like & getrecommendations! Published in 2019 at "Handbook of experimental pharmacology"
DOI: 10.1007/164_2019_244
Abstract: Functions for phospholipase D1 and D2 (PLD1 and PLD2), the canonical isoforms of the PLD superfamily in mammals, have been explored using cell biological and animal disease models for two decades. PLD1 and PLD2, which… read more here.
Keywords: disease; prospects pld; pld inhibition; inhibition cancer ... See more keywords
REV1-POL ζ Inhibition and Cancer Therapy.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular cell"
DOI: 10.1016/j.molcel.2019.07.012
Abstract: In a recent issue of Cell, Wojtaszek et al. (2019) reported a small-molecule inhibitor of mutagenic translesion DNA synthesis, which targets the interaction between REV1 and REV7, sensitizes cancer cells to cisplatin in vitro and in vivo, and… read more here.
Keywords: rev1 pol; pol inhibition; inhibition cancer; cancer ... See more keywords
Non-canonical Transcriptional Consequences of BET Inhibition in Cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Pharmacological research"
DOI: 10.1016/j.phrs.2019.104508
Abstract: Inhibition of the bromo and extra-terminal domain (BET) protein family in preclinical studies has demonstrated that BET proteins are critical for cancer progression and important therapeutic targets. Downregulation of the MYC oncogene, CDK6, BCL2 and… read more here.
Keywords: inhibition; bet inhibition; non canonical; inhibition cancer ... See more keywords
Photothermogenetic inhibition of cancer stemness by near-infrared-light-activatable nanocomplexes
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-17768-3
Abstract: Strategies for eradicating cancer stem cells (CSCs) are urgently required because CSCs are resistant to anticancer drugs and cause treatment failure, relapse and metastasis. Here, we show that photoactive functional nanocarbon complexes exhibit unique characteristics,… read more here.
Keywords: cancer; near infrared; inhibition cancer; cancer stemness ... See more keywords