Inhibition of carbonic anhydrase IX targets primary tumors, metastases, and cancer stem cells: Three for the price of one
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DOI: 10.1002/med.21497
Abstract: Human carbonic anhydrase (CA) IX is a tumor‐associated protein, since it is scarcely present in normal tissues, but highly overexpressed in a large number of solid tumors, where it actively contributes to survival and metastatic… read more here.
Keywords: carbonic anhydrase; anhydrase targets; inhibition carbonic; cancer ... See more keywords
Selective inhibition of carbonic anhydrase IX by sulphonylated 1,2,3-triazole incorporated benzenesulphonamides capable of inducing apoptosis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2022.2077333
Abstract: Abstract In search of selective carbonic anhydrase (CA) IX inhibitors endowed with apoptotic inducing properties, we designed and synthesised two subsets of 4- and 3-(5-aryl-(4-phenylsulphonyl)-1H-1,2,3-triazol-1-yl)benzenesulphonamides. All compounds were assayed for human carbonic anhydrase (hCA) isoforms… read more here.
Keywords: inhibition; carbonic anhydrase; selective inhibition; inhibition carbonic ... See more keywords
Inhibition of carbonic anhydrase II by sulfonamide derivatives.
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DOI: 10.1691/ph.2021.1590
Abstract: A series of sulfonamide derivatives were synthesized, and the enzyme inhibitory activity of the synthesized compounds on carbonic anhydrase II was evaluated. Through molecular docking studies, it was found that compounds 1b, 1e, 2a, 2b,… read more here.
Keywords: carbonic anhydrase; inhibition carbonic; sulfonamide derivatives; anhydrase sulfonamide ... See more keywords