Inhibition of caspase-1-mediated inflammasome activation reduced blood coagulation in cerebrospinal fluid after subarachnoid haemorrhage
Sign Up to like & getrecommendations! Published in 2022 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2022.103843
Abstract: Summary Background Neuroinflammation and blood coagulation responses in cerebrospinal fluid (CSF) contribute to the poor outcome associated with subarachnoid haemorrhage (SAH). We explored the role of caspase-1-mediated inflammasome activation on extrinsic blood coagulation in CSF… read more here.
Keywords: sah; inhibition caspase; caspase; blood coagulation ... See more keywords
Inhibition of caspase-1 prolongs survival of mice infected with rabies virus.
Sign Up to like & getrecommendations! Published in 2018 at "Vaccine"
DOI: 10.1016/j.vaccine.2018.04.002
Abstract: Rabies virus infects almost all mammals resulting in lethal disease. To date there is no treatment available for symptomatic rabies and there is an urgent need to develop treatment strategies that would prolong survival, thereby… read more here.
Keywords: rabies virus; response; inhibition caspase; inhibition ... See more keywords
The Inhibition of Caspase-1 Activity With a Dietary Polyphenol Reduces Anxiety and Depression in a Murine Model of Chronic Stress
Sign Up to like & getrecommendations! Published in 2021 at "Current Developments in Nutrition"
DOI: 10.1093/cdn/nzab037_078
Abstract: Polyphenols constitute a broad class of natural compounds with anti-oxidant properties. We previously demonstrated that polyphenol-rich dietary supplements confer resilience against stress-induced depressive behaviors. Here, we aimed to characterize the mechanism by which individual phenolic… read more here.
Keywords: stress; inhibition caspase; activity; anxiety depression ... See more keywords
Lipopolysaccharide Pre-conditioning Attenuates Pro-inflammatory Responses and Promotes Cytoprotective Effect in Differentiated PC12 Cell Lines via Pre-activation of Toll-Like Receptor-4 Signaling Pathway Leading to the Inhibition of Caspase-3/Nuclear Factor-Îșappa B Pathway
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2020.598453
Abstract: Lipopolysacharide (LPS) pre-conditioning (PC), has been shown to exert protective effects against cytotoxic effects. Therefore, we hypothesized, the tolerance produced by LPS PC will be resulted by the alterations and modifications in gene and protein… read more here.
Keywords: caspase; inhibition caspase; pre; signaling pathway ... See more keywords
Pharmacological Inhibition of Caspase-8 Suppresses Inflammation-Induced Angiogenesis in the Cornea
Sign Up to like & getrecommendations! Published in 2020 at "Biomolecules"
DOI: 10.3390/biom10020210
Abstract: Inflammation-induced angiogenesis is closely related to many diseases and has been regarded as a therapeutic target. Caspase-8 has attracted increasing attention for its immune properties and therapeutic potential in inflammatory disorders. The aim of our… read more here.
Keywords: caspase; inhibition caspase; induced angiogenesis; inflammation induced ... See more keywords