Direct inhibition of CaV2.3 by Gem is dynamin dependent and does not require a direct alfa/beta interaction.
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DOI: 10.1016/j.bbrc.2021.11.052
Abstract: The Rad, Rem, Rem2, and Gem/Kir (RGK) sub-family of small GTP-binding proteins are crucial in regulating high voltage-activated (HVA) calcium channels. RGK proteins inhibit calcium current by either promoting endocytosis or reducing channel activity. They… read more here.
Keywords: gem; dynamin dependent; inhibition cav2; cav2 channels ... See more keywords