Simultaneous inhibition of Chk1 and Bcl-xL induces apoptosis in vitro and represses tumour growth in an in vivo xenograft model.
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DOI: 10.1080/1120009x.2022.2125749
Abstract: We previously showed that prexasertib, a checkpoint kinase 1 (Chk1) inhibitor, and navitoclax, a Bcl-2 and Bcl-xL inhibitor, induced a synergistic inhibitory effect on cell proliferation in vitro. Here, we investigated the effect of the simultaneous… read more here.
Keywords: xenograft model; inhibition chk1; chk1 bcl; chk1 ... See more keywords