DYRK1A inhibition and cognitive rescue in a Down syndrome mouse model are induced by new fluoro-DANDY derivatives
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-20984-z
Abstract: Inhibition of DYRK1A kinase, produced by chromosome 21 and consequently overproduced in trisomy 21 subjects, has been suggested as a therapeutic approach to treating the cognitive deficiencies observed in Down syndrome (DS). We now report… read more here.
Keywords: mouse model; inhibition; inhibition cognitive; dyrk1a inhibition ... See more keywords
Brain activation patterns in medicated versus medication-naïve adults with attention-deficit hyperactivity disorder during fMRI tasks of motor inhibition and cognitive switching
Sign Up to like & getrecommendations! Published in 2021 at "BMC Medical Imaging"
DOI: 10.1186/s12880-021-00579-3
Abstract: Background Adult-attention-deficit-hyperactive-disorder (ADHD) is often unrecognized condition. FMRI examination along with neuropsychological testing might strengthen the diagnosis. We hypothesized that ADHD-adults with and without medication would show different fMRI pattern compared to healthy controls while… read more here.
Keywords: motor inhibition; tasks motor; medication; motor ... See more keywords