The in Vitro Antiplasmodial and Antiproliferative Activity of New Ferrocene‐Based α‐Aminocresols Targeting Hemozoin Inhibition and DNA Interaction
Sign Up to like & getrecommendations! Published in 2020 at "ChemBioChem"
DOI: 10.1002/cbic.202000132
Abstract: The conjugation of organometallic complexes to known bioactive organic frameworks is a proven strategy revered for devising new drug molecules with novel modes of action. This approach holds great promise for the generation of potent… read more here.
Keywords: hemozoin inhibition; antiplasmodial antiproliferative; dna; vitro antiplasmodial ... See more keywords
Inhibition of DNA-PKcs activity re-sensitizes uveal melanoma cells to radio- and chemotherapy.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.11.133
Abstract: Uveal melanoma (UM) is the most common primary intraocular tumor in adults. Despite of important progress in the local therapy, high radioresistance in primary tumor and chemoresistance in metastatic disease are the major obstacles for… read more here.
Keywords: chemotherapy; dna pkcs; dna; uveal melanoma ... See more keywords
Inhibition of NF-κB DNA binding suppresses myeloma growth via intracellular redox and tumor microenvironment modulation.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular cancer therapeutics"
DOI: 10.1158/1535-7163.mct-22-0257
Abstract: Multiple myeloma (MM) is a plasma cell malignancy that is still largely incurable, despite considerable progress in recent years. NF-κB is a well-established therapeutic target in MM, but none of the currently available treatment options… read more here.
Keywords: inhibition dna; suppresses myeloma; dna binding; binding suppresses ... See more keywords
Inhibition of DNA Repair Enzymes as a Valuable Pharmaceutical Approach
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DOI: 10.3390/ijms24097954
Abstract: The DNA repair system plays a crucial role in maintaining the integrity of the genome [...]. read more here.
Keywords: dna repair; enzymes valuable; dna; inhibition dna ... See more keywords
Inhibition of DNA-PK by gefitinib causes synergism between gefitinib and cisplatin in NSCLC
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Oncology"
DOI: 10.3892/ijo.2020.5103
Abstract: Lung cancer has the highest incidence and mortality rates among the malignant tumor types world-wide. Platinum-based chemotherapy is the main treatment for advanced non-small-cell lung cancer (NSCLC), and epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs)… read more here.
Keywords: gefitinib cisplatin; gefitinib; cisplatin nsclc; inhibition dna ... See more keywords