Inhibition of eIF4E signaling by ribavirin selectively targets lung cancer and angiogenesis.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.05.127
Abstract: Although the introduction of immune- and targeted-therapy has improved the clinical response and outcomes, lung cancer remains a therapeutic challenge. Developing new therapeutics is necessary to improve the treatment of lung cancer. Here, we show… read more here.
Keywords: cancer; inhibition eif4e; ribavirin; lung cancer ... See more keywords
Abstract 4462: Covalent inhibition of eIF4E: A computational approach
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-4462
Abstract: Covalent docking has emerged as a promising strategy for targeting challenging protein residues. Specifically, lysine residues, which are often overlooked due to their lower nucleophilicity compared to cysteines, have shown potential in the development of… read more here.
Keywords: covalent inhibition; lysine residues; inhibition; eif4e computational ... See more keywords